ArticleJournal of assisted reproduction and genetics2012
Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis.
Article in Journal of assisted reproduction and genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Genotoxicity and acute toxicity of Hyunburikyung-tang: assessing the safety of prescribing traditional Korean medicine for dysmenorrhea.BMC complementary medicine and therapies · 2025Article
- Bioactive Substances in Safflower Flowers and Their Applicability in Medicine and Health-Promoting Foods.International journal of food science · 2021Review
- Chinese medicinal plants for the potential management of high-altitude pulmonary oedema and pulmonary hypertension.Pharmaceutical biology · 2020Review
- Protective effects of melatonin solid lipid nanoparticles on testis histology after testicular trauma in rats.Research in pharmaceutical sciences · 2019Article
- Natural Medicines Used in the Traditional Tibetan Medical System for the Treatment of Liver Diseases.Frontiers in pharmacology · 2018Review
- Valproic acid induces histologic changes and decreases androgen receptor levels of testis and epididymis in rats.International journal of reproductive biomedicine · 2017Article
- Protective effects of melatonin on testis histology following acute torsion-detorsion in rats.International journal of reproductive biomedicine · 2017Article
- Beneficial effects of quercetin on titanium dioxide nanoparticles induced spermatogenesis defects in mice.Environmental science and pollution research international · 2017Article
- Preventive effects of betulinic acid on streptozotocinnicotinamide induced diabetic nephropathy in male mouse.Journal of nephropathology · 2016Article
- Effects of hydro-alcoholic extract ofIranian journal of veterinary research · 2016Article
- Effect of beta-carotene on titanium oxide nanoparticles-induced testicular toxicity in mice.Journal of assisted reproduction and genetics · 2014Article
- Histological, ultrastructural and biochemical studies on the kidney of mice treated with Carthamus tinctorius L. extract.Avicenna journal of phytomedicine · 2013Article
- Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice.Avicenna journal of phytomedicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of aqueous extract of Carthamus tinctorius L., also named safflower, on mouse spermatogenesis.
methodsSixteen adult male NMRI mice were used. Experimental group received Carthamus tinctorius L. extract at the dose of 200 mg/kg for 35 consecutive days and control group received only distilled water. Testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the Carthamus tinctorius L. extract effects on testis.
resultsHistopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly decreased in Carthamus tinctorius L. treated mice (p < 0.001). Carthamus tinctorius L. extract induced formation of multinucleated giant cells in the germinal epithelium. Carthamus tinctorius L. extract also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p < 0.001).
conclusionCarthamus tinctorius L. extract has toxic effects on mouse testicular tissue, and recommended to use it with caution if there is a reproductive problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.