ReviewNature reviews. Neuroscience2012
The ageing cortical synapse: hallmarks and implications for cognitive decline.
Review in Nature reviews. Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 561 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction
StimoLaMente - La Stimolazione Cerebrale Non Invasiva Applicata Alla Riabilitazione Della Malattia di Alzheimer/ StimoLaMente - Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Who cites it
561 citing papers in PubMed, 7 syntheses or guidelines pooled it, 951 citations in OpenAlex.
- Effectiveness and safety of intravenous thrombolysis for non-arteritic central retinal artery occlusion: A GRADE-assessed meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Pooled it
- Efficacy of non-invasive neuromodulation technologies in improving cognitive function and activities of daily living in patients with Alzheimer's disease, Parkinson's disease, and stroke: a systematic review and network meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Dietary diversity and cognitive performance in older adults: a systematic review.BMC neurology · 2025Pooled it
- Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Is Hormone Replacement Therapy a Risk Factor or a Therapeutic Option for Alzheimer's Disease?International journal of molecular sciences · 2023Pooled it
- Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Clinical Soma and Neurite Density Imaging (SANDI): Translational Microstructure Mapping on Clinical 3T MRI Scanners.Magnetic resonance in medicine · 2026Article
- Age-related changes in synapse ultrastructure and neuroprotective effect of dietary curcumin in the lateral prefrontal cortex layer 3 of the rhesus monkey.GeroScience · 2026Article
- Age-Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC.The Journal of comparative neurology · 2026Article
- Plasma and cerebrospinal fluid proteomics reveal distinct patterns of senescence and neuropathology in aging rhesus macaques.GeroScience · 2026Article
- Age-Related Changes in Spontaneous Brain Dynamics Revealed by Resting-State Magnetoencephalography.GeroScience · 2026Article
- DietaryJournal of microbiology and biotechnology · 2026Article
- Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age-Related Cognitive Inflexibility in Mice.Aging cell · 2026Article
- A scalable touchscreen-based spatial working memory task for cross-species research.Neurobiology of learning and memory · 2026Article
- Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging.Cellular and molecular life sciences : CMLS · 2026Article
- Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging.Biomolecules · 2026Review
- Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes.Molecular psychiatry · 2026Article
- Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.Molecular biomedicine · 2026Article
- Multimodal Signatures of Brain Aging: From Descriptive Analyses to Machine Learning-Based Integration.International journal of molecular sciences · 2026Article
501 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Normal ageing is associated with impairments in cognitive function, including memory. These impairments are linked, not to a loss of neurons in the forebrain, but to specific and relatively subtle synaptic alterations in the hippocampus and prefrontal cortex. Here, we review studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals. We also discuss the influence of the hormonal status on these age-related alterations and recent progress in the development of therapeutic strategies to limit the impact of ageing on memory and cognition in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.