Trial reportCephalalgia : an international journal of headache2012
Migraine and restless legs syndrome in women.
Trial report in Cephalalgia : an international journal of headache, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- The Prevalence of Restless Legs Syndrome in Patients with Migraine: A Systematic Review and Meta-Analysis.Pain research & management · 2020Pooled it
- Restless legs syndrome associated with major diseases: A systematic review and new concept.Neurology · 2016Pooled it
- Mechanistic Overlaps Between Sleep and Headache Disorders: From Dopaminergic Dysfunction to Neuroinflammation-A Narrative Review.Clocks & sleep · 2026Review
- Restless legs syndrome and sleep quality in children with migraine and tension-type headache.PeerJ · 2026Article
- Clinical profile of restless leg syndrome and its effect on sleep and quality of life.Journal of family medicine and primary care · 2025Article
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Patterns of gray matter alterations in migraine and restless legs syndrome.Annals of clinical and translational neurology · 2019Article
- Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms.Headache · 2018Review
- Non-headache symptoms in migraine patients.F1000Research · 2018Review
- Altered Brain Functional Connectome in Migraine with and without Restless Legs Syndrome: A Resting-State Functional MRI Study.Frontiers in neurology · 2018Article
- Excessive daytime sleepiness is associated with an exacerbation of migraine: A population-based study.The journal of headache and pain · 2016Article
- Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study.The journal of headache and pain · 2016Article
- Relationship between primary restless legs syndrome and migraine with aura.The Kaohsiung journal of medical sciences · 2016Article
- Increased Risk of Restless Legs Syndrome in Patients With Migraine: A Nationwide Population-Based Cohort Study.Medicine · 2016Article
- Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity.Sleep · 2016Article
- Risk of Restless Legs Syndrome Following Tension-Type Headache: A Nationwide Population-Based Cohort Study.Medicine · 2015Observational
- Migraine and restless legs syndrome are associated in adults under age fifty but not in adults over fifty: a population-based study.The journal of headache and pain · 2015Article
- Structural brain lesions and restless legs syndrome: a cross-sectional population-based study.BMJ open · 2014Article
- Restless legs syndrome and pain disorders: what's in common?Current pain and headache reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundFew clinic-based studies report an association between migraine and restless legs syndrome (RLS); however, population-based data are unavailable.
methodsCohort study among 31,370 women participating in the Women's Health Study. We had detailed self-reported information on migraine, including aura status, and RLS. RLS was ascertained at the 9-year follow-up. We calculated odds ratios (OR) and 95% confidence intervals (CI) for the association between migraine and RLS. We investigated any indication of migraine until RLS ascertainment as well as migraine with and without aura at baseline, prior migraine before baseline, and new reports of migraine during follow-up.
resultsAt baseline or during follow-up 6857 (21.9%) women reported any migraine. These women had an increased risk for RLS (multivariable-adjusted OR = 1.22; 95%CI 1.13-1.32). Further analyses indicated a similar association for migraine with aura (multivariable-adjusted OR = 1.27; 95%CI 1.10-1.48) and migraine without aura (multivariable-adjusted OR = 1.24; 95%CI 1.09-1.40) as well as for new reports of migraine during follow-up (multivariable-adjusted OR = 1.30; 95%CI 1.10-1.54). Prior migraine did not appear to be associated with RLS.
conclusionsOur data suggest an association between migraine and RLS at the population level. The association is similar for migraine with and without aura and for new reports of migraine during follow-up.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.