ReviewDevelopment (Cambridge, England)2012
Fluid flows and forces in development: functions, features and biophysical principles.
Review in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- Real-Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform.Cancer immunology, immunotherapy : CII · 2026Article
- Article
- Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms.NPJ microgravity · 2026Article
- Motile cilia spin the Reissner fiber, a tensioned and anchored extracellular thread essential for body morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Utility of anLab on a chip · 2025Article
- Defining conceptual artefacts to manage and design simplicities in complex adaptive systems.Heliyon · 2024Article
- Coacervate Dense Phase Displaces Surface-EstablishedJournal of the American Chemical Society · 2024Article
- Haemodynamic Forces: Emerging Markers of Ventricular Remodelling in Multiple Myeloma Cardiovascular Baseline Risk Assessment.Cancers · 2024Article
- Calpain Small Subunit Mediated Secretion of Galectin-3 Regulates Traction Stress.Biomedicines · 2024Article
- Directional Cell Migration Guided by a Strain Gradient.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis.EMBO reports · 2023Article
- Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos.iScience · 2023Article
- Pathway to Independence: the future of developmental biology.Development (Cambridge, England) · 2023Article
- Measuring flow-mediated protein drift across stationary supported lipid bilayers.Biophysical journal · 2023Article
- Harnessing mechanobiology for kidney organoid research.Frontiers in cell and developmental biology · 2023Review
- Engineering Organ-on-a-Chip to Accelerate Translational Research.Micromachines · 2022Review
- Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow.Biofabrication · 2022Article
- Extracellular Fluid Flow Induces Shallow Quiescence Through Physical and Biochemical Cues.Frontiers in cell and developmental biology · 2022Article
- Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling.PLoS biology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Throughout morphogenesis, cells experience intracellular tensile and contractile forces on microscopic scales. Cells also experience extracellular forces, such as static forces mediated by the extracellular matrix and forces resulting from microscopic fluid flow. Although the biological ramifications of static forces have received much attention, little is known about the roles of fluid flows and forces during embryogenesis. Here, we focus on the microfluidic forces generated by cilia-driven fluid flow and heart-driven hemodynamics, as well as on the signaling pathways involved in flow sensing. We discuss recent studies that describe the functions and the biomechanical features of these fluid flows. These insights suggest that biological flow determines many aspects of cell behavior and identity through a specific set of physical stimuli and signaling pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.