ArticleVirchows Archiv : an international journal of pathology2012
Deregulation of a distinct set of microRNAs is associated with transformation of gastritis into MALT lymphoma.
Article in Virchows Archiv : an international journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.Digestive diseases and sciences · 2021Article
- Non-coding RNAs (miRNAs and lncRNAs) and their roles in lymphogenesis in all types of lymphomas and lymphoid malignancies.Oncology letters · 2021Review
- Predicting miRNA-Disease Association Based on Modularity Preserving Heterogeneous Network Embedding.Frontiers in cell and developmental biology · 2021Article
- Ensemble of decision tree reveals potential miRNA-disease associations.PLoS computational biology · 2019Article
- Deregulation of miRNA inJournal of clinical medicine · 2019Article
- MicroRNA profiles in B-cell non-Hodgkin lymphoma.EJIFCC · 2019Review
- Deciphering splenic marginal zone lymphoma pathogenesis: the proposed role of microRNA.Oncotarget · 2018Review
- MicroRNAs as Biomarkers of B-cell Lymphoma.Biomarker insights · 2018Review
- Clinical manifestations and epigenetic mechanisms of gastric mucosa associated lymphoid tissue lymphoma and long-term follow-up followingExperimental and therapeutic medicine · 2018Article
- GRMDA: Graph Regression for MiRNA-Disease Association Prediction.Frontiers in physiology · 2018Article
- Article
- MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.Cancer genomics & proteomics · 2017Article
- Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model ofFrontiers in cellular and infection microbiology · 2017Article
- Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.International journal of molecular sciences · 2016Review
- miR-155 as a Biomarker in B-Cell Malignancies.BioMed research international · 2016Review
- MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential.Current genomics · 2015Article
- Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.World journal of gastroenterology · 2014Review
- Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma.World journal of gastroenterology · 2013Review
- Review
- MicroRNA: A Bridge from H. pylori Infection to Gastritis and Gastric Cancer Development.Frontiers in genetics · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the transformation from chronic Helicobacter pylori gastritis to gastric extranodal marginal zone lymphoma (MALT lymphoma) are poorly understood. This study aims to identify microRNAs that might be involved in the process of neoplastic transformation. We generated microRNA signatures by RT-PCR in 68 gastric biopsy samples representing normal mucosa, gastritis, suspicious lymphoid infiltrates, and overt MALT lymphoma according to Wotherspoon criteria. Analyses revealed a total of 41 microRNAs that were significantly upregulated (n = 33) or downregulated (n = 8) in succession from normal mucosa to gastritis and to MALT lymphoma. While some of these merely reflect the presence of lymphocytes (e.g. miR-566 and miR-212) or H. pylori infection (e.g. miR-155 and let7f), a distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma. This differential expression might therefore indicate a central role of these microRNAs in the process of malignant transformation.
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