ArticleVirchows Archiv : an international journal of pathology2012
Etiological factors in primary hepatic B-cell lymphoma.
Article in Virchows Archiv : an international journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Management approaches for primary hepatic lymphoma: 10 year institutional experience with comprehensive literature review.Frontiers in oncology · 2025Article
- Primary Hepatic EBV-DLBCL Lymphoma in the Setting of COVID-19 Infection.ACG case reports journal · 2024Article
- Multimodality Imaging of Primary Hepatic Lymphoma: A Case Report and a Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Contrast-enhanced ultrasound findings of primary hepatic non-Hodgkin's lymphoma: a case report.Frontiers in oncology · 2024Article
- Primary hepatic mucosa-associated lymphoid tissue lymphoma mimicking hepatocellular carcinoma in a patient with chronic hepatitis B: a case report.The Journal of international medical research · 2023Article
- Article
- Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management.Frontiers in oncology · 2022Review
- Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study.World journal of clinical cases · 2021Article
- Primary hepatic lymphoma diagnosed using endoscopic ultrasound-guided liver biopsy: a case report.Journal of medical case reports · 2021Article
- Article
- Review
- Non-Hodgkin Lymphoma of the Liver: A US Population-based Analysis.Journal of clinical and translational hepatology · 2017Article
- Review
- An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review.SAGE open medical case reports · 2017Article
- A case of multiple hepatic lesions associated with methotrexate-associated lymphoproliferative disorder.Journal of medical ultrasonics (2001) · 2016Article
- Article
- Primary rectal mucosa-associated lymphoid tissue lymphoma in a patient with previously identified primary biliary cirrhosis and secondary Sjögren's syndrome.Clinical journal of gastroenterology · 2016Article
- A Case of Primary Hepatic Lymphoma and Related Literature Review.Case reports in hepatology · 2016Article
- Primary Diffuse Large B-Cell Lymphoma of the Liver in a Patient with Sjogren Syndrome.Case reports in oncological medicine · 2016Article
- Complete response to comprehensive treatment of a primary hepatic diffuse large B cell lymphoma: A case report.Oncology letters · 2015Article
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sixty-four cases of malignant lymphoma involving the liver were examined. Of these, 20 cases were histologically confirmed to be primary hepatic B-cell lymphoma. Twelve of these 20 cases were diffuse large B-cell lymphoma (DLBCL) and eight cases were mucosa-associated lymphoid tissue (MALT) lymphoma. Of the 12 cases of DLBCL, six were immunohistologically positive for CD10 and/or Bcl6 (indicating a germinal center phenotype), six were positive for Bcl2, and five were positive for CD25. Eight of the 12 DLBCL cases (66.7%) and two of the eight MALT lymphoma cases (25%) had serum anti-hepatitis C virus (HCV) antibodies and HCV RNA. The incidence of HCV infection was significantly higher in the hepatic DLBCL cases than in systemic intravascular large B-cell cases with liver involvement (one of 11 cases, 9.1%) and T/NK-cell lymphoma cases (one of 19 cases, 5.3%) (p < 0.01 for both). Two hepatic DLBCL cases (16.7%) had rheumatoid arthritis treated with methotrexate, and four MALT lymphoma cases (50%) had Sjögren's syndrome, primary biliary cirrhosis, or autoimmune hepatitis; one case in each of these two groups was complicated by chronic HCV-seropositive hepatitis. Although primary hepatic lymphoma is rare, persistent inflammatory processes associated with HCV infection or autoimmune disease may play independent roles in the lymphomagenesis of hepatic B cells.
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