ArticleMolecular systems biology2012
The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops.
Article in Molecular systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers.
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Who cites it
210 citing papers in PubMed.
- Circadian- and light-regulated oscillatory expression of CSA in rice leaves is required for pollen fertility.Plant cell reports · 2026Article
- Molecular genetic examination of Circadian Clock Associated 1 gene (CCA1) in hexaploid wheat.BMC plant biology · 2026Article
- Counting Subnetworks Under Gene Duplication in Genetic Regulatory Networks.Bulletin of mathematical biology · 2026Article
- Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants.Npj biological timing and sleep · 2026Article
- Temperature compensation of the Arabidopsis circadian clock.Npj biological timing and sleep · 2025Review
- A CRISPR/Cas9-induced restoration of bioluminescence reporter system for single-cell gene expression analysis in plants.Scientific reports · 2025Article
- Coincidence of the threshold temperature of seasonal switching for diel transcriptomic oscillations and growth.Plant & cell physiology · 2025Article
- EnhancingFood chemistry: X · 2025Article
- Review
- Abundant clock proteins point to missing molecular regulation in the plant circadian clock.Molecular systems biology · 2025Article
- Designing biological network motif-based controllers by reverse engineering Hill function-type models from linear models.Journal of the Royal Society, Interface · 2025Article
- Data-driven model discovery and model selection for noisy biological systems.PLoS computational biology · 2025Article
- Decoding the plant clock: a review of mathematical models for the circadian regulatory network.Plant molecular biology · 2024Review
- Timely symbiosis: circadian control of legume-rhizobia symbiosis.Biochemical Society transactions · 2024Review
- Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.Genetics · 2024Article
- Core clock genes adjust growth cessation time to day-night switches in poplar.Nature communications · 2024Article
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- Review
- Transcription factor module NLP-NIGT1 fine-tunes NITRATE TRANSPORTER2.1 expression.Plant physiology · 2023Article
- Comparative Analysis of Circadian Transcriptomes Reveals Circadian Characteristics betweenPlants (Basel, Switzerland) · 2023Article
150 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can be essential for gene expression rhythms in plants. Integrating the EC components in this role significantly alters our mechanistic, mathematical model of the clock gene circuit. Negative autoregulation of the EC genes constitutes the clock's evening loop, replacing the hypothetical component Y. The EC explains our earlier conjecture that the morning gene Pseudo-Response Regulator 9 was repressed by an evening gene, previously identified with Timing Of CAB Expression1 (TOC1). Our computational analysis suggests that TOC1 is a repressor of the morning genes Late Elongated Hypocotyl and Circadian Clock Associated1 rather than an activator as first conceived. This removes the necessity for the unknown component X (or TOC1mod) from previous clock models. As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.