ArticlePsychopharmacology2012
Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
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- Sex differences in the neural circuitry of aggression.bioRxiv : the preprint server for biology · 2025Article
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- Whole-genome re-sequencing association study for direct genetic effects and social genetic effects of six growth traits in Large White pigs.Scientific reports · 2019Article
- Review of Sensor Technologies in Animal Breeding: Phenotyping Behaviors of Laying Hens to Select Against Feather Pecking.Animals : an open access journal from MDPI · 2019Review
- The genetic architecture of socially-affected traits: a GWAS for direct and indirect genetic effects on survival time in laying hens showing cannibalism.Genetics, selection, evolution : GSE · 2018Article
- Paradoxical effect of baclofen on social behavior in the fragile X syndrome mouse model.Brain and behavior · 2018Article
- Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.Physiological reports · 2017Article
- Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states.Neuropharmacology · 2015Review
- Alcohol and violence: neuropeptidergic modulation of monoamine systems.Annals of the New York Academy of Sciences · 2015Review
- High-frequency stimulation of the medial prefrontal cortex decreases cellular firing in the dorsal raphe.The European journal of neuroscience · 2015Article
- Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neurogenetics of aggressive behavior: studies in rodents.Current topics in behavioral neurosciences · 2014Review
- Effect of Extremely Low Frequency Electromagnetic Field and/or GABAB Receptors on Foot Shock-induced Aggression in Rats.Basic and clinical neuroscience · 2014Article
- Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat.Frontiers in behavioral neuroscience · 2014Article
- Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
rationalePharmacological activation of GABA(B) receptors in the dorsal raphe nucleus (DRN) can escalate territorial aggression in male mice.
objectivesWe characterized this escalated aggression in terms of its behavioral and environmental determinants.
methodsAggressive behavior of resident male (CFW or ICR mouse) was assessed in confrontations with a group-housed intruder. Either baclofen (0.06 nmol/0.2 μl) or vehicle (saline) was microinjected into the DRN 10 min before the confrontation. We examined baclofen-heightened aggression in five situations: aggression in a neutral arena and after social instigation (experiment 1), aggression during the light phase of the cycle (experiment 2), aggression without prior fighting experience (experiment 3), aggression toward a female (experiment 4), and aggression after defeat experiences (experiment 5). In addition, we examined the body targets towards which bites are directed and the duration of aggressive bursts after baclofen treatment.
resultsRegardless of the past social experience, baclofen escalated aggressive behaviors. Even in the neutral arena and after defeat experiences, where aggressive behaviors were inhibited, baclofen significantly increased aggression. Baclofen increased attack bites directed at vulnerable body areas of male intruders but not toward a female and only in the dark. Also, baclofen prolonged the duration of aggressive bursts.
conclusionsFor baclofen to escalate aggression, specific stimulation (male intruder) and tonic level of serotonin (dark cycle) are required. Once aggressive behavior is triggered, intra-DRN baclofen escalates the level of aggression to abnormal levels and renders it difficult to terminate. Also, baclofen counteracts the effects of novelty or past experiences of defeat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.