ReviewPflugers Archiv : European journal of physiology2012
Special features of mitochondrial Ca²⁺ signalling in adrenal glomerulosa cells.
Review in Pflugers Archiv : European journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications.Endocrine reviews · 2018Review
- Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- No evidence for a local renin-angiotensin system in liver mitochondria.Scientific reports · 2013Article
- Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells.Pflugers Archiv : European journal of physiology · 2012Review
- A Special Issue on the cell-specific roles of mitochondrial Ca²⁺ handling.Pflugers Archiv : European journal of physiology · 2012Article
- Mitochondrial function and malfunction in the pathophysiology of pancreatitis.Pflugers Archiv : European journal of physiology · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldosterone, secreted by adrenal glomerulosa cells, allows the adaptation of the vertebrate organism to a wide range of physiological and pathological stimuli including acute haemodynamic challenges and long-term changes in dietary sodium and potassium intake. Most of the extracellular signals are mediated by cytosolic Ca²⁺ signal deriving from Ca²⁺ release, store-operated and/or voltage-gated Ca²⁺ influx. Mitochondria in glomerulosa cells play a fundamental role in generating and modulating the final biological response. These organelles not only house several enzymes of aldosterone biosynthesis but also-in a Ca²⁺-dependent manner-provide NADPH for the function of these enzymes. Moreover, mitochondria, constituting a high portion of cytoplasmic volume and displaying a uniquely low-threshold Ca²⁺ sequestering ability, shape and thus modulate the decoding of the complex cytosolic Ca²⁺ response. The unusual features of mitochondrial Ca²⁺ signalling that permit such an integrative function in adrenal glomerulosa cells are hereby described.
Indexed as
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Registered trials
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