ArticleHuman molecular genetics2012
Imprinting control region (ICR) of the Peg3 domain.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos.The Journal of biological chemistry · 2026Article
- Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.Nucleic acids research · 2025Article
- Generation of live mice from haploid ESCs with germline-DMR deletions or switch.Cell discovery · 2025Article
- Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.World journal of pediatrics : WJP · 2025Article
- Biological characteristics and immune responses of NK Cells in commonly used experimental mouse models.Frontiers in immunology · 2024Review
- PEG3 controls lipogenesis through ACLY.PloS one · 2021Article
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- Differentially methylated region in bovine MIMT1 detected by small-scale whole-genome methylation sequencing.Journal of applied genetics · 2019Article
- A mouse model of Angelman syndrome imprinting defects.Human molecular genetics · 2019Article
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- The imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.Scientific reports · 2018Article
- Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells.Nature communications · 2018Article
- Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers.Human molecular genetics · 2018Article
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- Article
- Allele and dosage specificity of the Peg3 imprinted domain.PloS one · 2018Article
- The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.Molecular cell · 2017Article
- YY1's role in the Peg3 imprinted domain.Scientific reports · 2017Article
- Transcription-driven DNA methylation setting on the mouse Peg3 locus.Epigenetics · 2017Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
The imprinting and transcription of the 500 kb genomic region surrounding the mouse Peg3 is predicted to be regulated by the Peg3-differentially methylated region (DMR). In the current study, this prediction was tested using a mutant mouse line lacking this potential imprinting control region (ICR). At the organismal level, paternal and maternal transmission of this knockout (KO) allele caused either reduced or increased growth rates in the mouse, respectively. In terms of the imprinting control, the paternal transmission of the KO allele resulted in bi-allelic expression of the normally maternally expressed Zim2, whereas the maternal transmission switched the transcriptionally dominant allele for Zfp264 (paternal to maternal). However, the allele-specific DNA methylation patterns of the DMRs of Peg3, Zim2 and Zim3 were not affected in the mice that inherited the KO allele either paternally or maternally. In terms of the transcriptional control, the paternal transmission caused a dramatic down-regulation in Peg3 expression, but overall up-regulation in the other nearby imprinted genes. Taken together, deletion of the Peg3-DMR caused global changes in the imprinting and transcription of the Peg3 domain, confirming that the Peg3-DMR is an ICR for this imprinted domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.