ArticleDevelopmental biology2012
Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Article
- The Eyes Absent proteins in development and in developmental disorders.Biochemical Society transactions · 2021Review
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.Scientific reports · 2016Article
- optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.Developmental biology · 2013Article
- The Eyes Absent proteins in development and disease.Cellular and molecular life sciences : CMLS · 2013Review
- Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.Developmental biology · 2013Article
- Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.PloS one · 2012Article
- MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The retinal determination gene network comprises a collection of transcription factors that respond to multiple signaling inputs to direct Drosophila eye development. Previous genetic studies have shown that nemo (nmo), a gene encoding a proline-directed serine/threonine kinase, can promote retinal specification through interactions with the retinal determination gene network, although the molecular point of cross-talk was not defined. Here, we report that the Nemo kinase positively and directly regulates Eyes absent (Eya). Genetic assays show that Nmo catalytic activity enhances Eya-mediated ectopic eye formation and potentiates induction of the Eya-Sine oculis (So) transcriptional targets dachshund and lozenge. Biochemical analyses demonstrate that Nmo forms a complex with and phosphorylates Eya at two consensus mitogen-activated protein kinase (MAPK) phosphorylation sites. These same sites appear crucial for Nmo-mediated activation of Eya function in vivo. Thus, we propose that Nmo phosphorylation of Eya potentiates its transactivation function to enhance transcription of Eya-So target genes during eye specification and development.
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Registered trials
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