ReviewNeurotoxicology2012
Non-coding RNAs--novel targets in neurotoxicity.
Review in Neurotoxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- The Role of Epigenetics in Manganese Neurotoxicity: An Update with a Focus on Non-Coding RNAs and Histone Modifications.Neurochemical research · 2025Review
- Leveraging a meta-learning approach to advance the accuracy of NaScientific reports · 2024Article
- Neuroprotective effects of quercetin on the cerebellum of zinc oxide nanoparticles (ZnoNps)-exposed rats.Tissue barriers · 2023Article
- MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy.Molecular neurobiology · 2022Review
- Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats.Toxicology research · 2019Article
- Triazophos-induced toxicity in zebrafish:Toxicology research · 2018Article
- ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN.Green chemistry : an international journal and green chemistry resource : GC · 2016Article
- Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
- Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response.Toxicology research · 2016Article
- A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis.Archives of toxicology · 2016Article
- Alteration of microRNA expressions in the pons and medulla in rats after 3,3'-iminodipropionitrile administration.Journal of toxicologic pathology · 2016Article
- A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections.Virology journal · 2016Review
- Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion.Experimental brain research · 2016Article
- Genome wide discovery of long intergenic non-coding RNAs in Diamondback moth (Plutella xylostella) and their expression in insecticide resistant strains.Scientific reports · 2015Article
- Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAP.Molecular endocrinology (Baltimore, Md.) · 2014Article
- The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate.PloS one · 2014Article
- Article
- Overlapped metabolic and therapeutic links between Alzheimer and diabetes.Molecular neurobiology · 2013Review
- Decoding the non-coding RNAs in Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Over the past ten years non-coding RNAs (ncRNAs) have emerged as pivotal players in fundamental physiological and cellular processes and have been increasingly implicated in cancer, immune disorders, and cardiovascular, neurodegenerative, and metabolic diseases. MicroRNAs (miRNAs) represent a class of ncRNA molecules that function as negative regulators of post-transcriptional gene expression. miRNAs are predicted to regulate 60% of all human protein-coding genes and as such, play key roles in cellular and developmental processes, human health, and disease. Relative to counterparts that lack bindings sites for miRNAs, genes encoding proteins that are post-transcriptionally regulated by miRNAs are twice as likely to be sensitive to environmental chemical exposure. Not surprisingly, miRNAs have been recognized as targets or effectors of nervous system, developmental, hepatic, and carcinogenic toxicants, and have been identified as putative regulators of phase I xenobiotic-metabolizing enzymes. In this review, we give an overview of the types of ncRNAs and highlight their roles in neurodevelopment, neurological disease, activity-dependent signaling, and drug metabolism. We then delve into specific examples that illustrate their importance as mediators, effectors, or adaptive agents of neurotoxicants or neuroactive pharmaceutical compounds. Finally, we identify a number of outstanding questions regarding ncRNAs and neurotoxicity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.