Evidence map›Paper›PMID 22394260›Full record

ArticleAIDS research and human retroviruses2012

Short communication: adhesion pathways utilized by HIV-infected lymphocytes.

Yu-hua Chow, Li Liu, Barbara Schwartz, John M Harlan, Lynn M Schnapp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yu-hua ChowDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Li Liu
Barbara Schwartz
John M Harlan
Lynn M Schnapp
University of Washington · US

Funding

VLA-4 and VCAM-1 in Advanced AtherosclerosisP01HL018645 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHAIT, ALAN · 1985 to 2010
$23.9M
Matrix remodeling in the lung during HIV infectionR01HL083481 · NHLBI · UNIVERSITY OF WASHINGTON · PI SCHNAPP, LYNN M · 2005 to 2009
$1.9M
NHLBI NIH HHS HL083481NHLBI NIH HHS HL18645NHLBI NIH HHS K24 HL068796
6 · The paper itself

Abstract

We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. We further demonstrate that HIV-infected lymphocytes require Rap-1 activity for phorbol-stimulated adhesion. Understanding adhesion pathways used by HIV-infected lymphocytes may lead to interventions to regulate aberrant adhesion and migration.

Indexed as

Cell AdhesionCells, CulturedCyclin-Dependent Kinase 4Endothelial CellsFibronectinsHIVHumansLymphocytesCDK4 protein, humanCyclin-Dependent Kinase 4Fibronectins

Identifiers

PMID22394260
PMCPMC3505057
OpenAlexW2066748148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.