ArticleJournal of alternative and complementary medicine (New York, N.Y.)2012
Genome-wide association analysis of Sasang constitution in the Korean population.
Article in Journal of alternative and complementary medicine (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Exploring Stroke Risk through Mendelian Randomization: A Comprehensive Study Integrating Genetics and Metabolic Traits in the Korean Population.Biomedicines · 2024Article
- Sasang Constitution May Act as a Risk Factor for Depressive Symptoms-A Survey for Local Residence.Healthcare (Basel, Switzerland) · 2022Article
- Hot and Cold Theory: Evidence in Systems Biology.Advances in experimental medicine and biology · 2021Article
- Comparative gut microbiome analysis of the3 Biotech · 2020Article
- Analysis of Sasang Constitutional Medicine as an Optimal Preventive Care Strategy for Hemophilia Patients.BioMed research international · 2020Article
- Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS andEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Genetic and Environmental Overlaps Among Sasang Constitution Types: A Multivariate Twin Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018Article
- A Pilot Study on Characteristics of Metabolomics and Lipidomics according to Sasang Constitution.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study.Integrative medicine research · 2017Article
- Body temperature regulation: Sasang typology-based perspective.Integrative medicine research · 2015Review
- Non-alcoholic fatty liver disease among sasang constitutional types: a population-based study in Korea.BMC complementary and alternative medicine · 2015Article
- Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine.BMC complementary and alternative medicine · 2015Article
- Sasang constitution affects the prevalence of functional dyspepsia.BMC complementary and alternative medicine · 2015Article
- The obesity-risk variant of FTO is inversely related with the So-Eum constitutional type: genome-wide association and replication analyses.BMC complementary and alternative medicine · 2015Article
- Constitutional multicenter bank linked to Sasang constitutional phenotypic data.BMC complementary and alternative medicine · 2015Article
- Serum Levels of Stress Hormones and Oxidative Stress Biomarkers Differ according to Sasang Constitutional Type.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans.BMC complementary and alternative medicine · 2014Article
- Development and evaluation of the first high-throughput SNP array for common carp (Cyprinus carpio).BMC genomics · 2014Article
- Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.Lipids in health and disease · 2014Article
- Re-interpretation of traditional Asian medicine with constitutional perspective.Integrative medicine research · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSasang constitutional medicine is a traditional Korean medicine in which an individual is classified into one of four types of constitution: Taeum (TE), Soeum (SE) Soyang (SY), and Taeyang (TY). These constitution types are determined with biologic and physiologic characteristics, so it has been assumed that genetic factors are associated with each constitution type. Identifying the genetic elements underlying each constitution is necessary for the elucidation of the molecular mechanism of Sasang constitutional medicine.
designA total of 341,998 genetic loci across the whole genome were genotyped for 1222 subjects of defined constitution type. The genetic loci associated with each constitution type were identified and the functional connectivity of genes within these loci was analyzed using statistical text mining.
resultsFrom the difference in allele frequencies between constitution types, significant genetic loci associated with each type were identified. Chromosomes 3q27.3 (rs10937331, p=2.71×10(-6)), 15q22.2 (rs7180547, p=1.58×10(-6)), and 14q22.3 (rs12431592, p=1.31×10(-6)) were most significantly associated with TE, SE, and SY constitution types, respectively. From the functional relationship analysis using all loci with a p-value≤10(-4), genes associated with each constitution type were identified. Fifteen (15) genes, including GPM6A, SYT4, and GRIK1, were significantly associated with the TE constitution type (p<0.05); 12 genes, including DRGX and AKAP11, were significantly associated with the SE constitution type (p<0.05); and 17 genes, including ZFP42, CDH22, ALDH1A2, OTX2, and EN2, were significantly associated with the SY constitution type (p<0.05).
conclusionsGenetic loci and genes associated with Sasang constitution types were systematically identified from a genome-wide association study using a large number of subjects.
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