ArticleThe European journal of neuroscience2012
A goal-directed spatial navigation model using forward trajectory planning based on grid cells.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 212 citations in OpenAlex.
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026Review
- Review
- Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space.bioRxiv : the preprint server for biology · 2025Article
- Grid cells accurately track movement during path integration-based navigation despite switching reference frames.Nature neuroscience · 2025Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Deep Learning-Emerged Grid Cells-Based Bio-Inspired Navigation in Robotics.Sensors (Basel, Switzerland) · 2025Review
- Article
- Phase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells.Hippocampus · 2025Article
- A systems model of alternating theta sweeps via firing rate adaptation.Current biology : CB · 2025Article
- Navigation: Scanning your future path.Current biology : CB · 2025Article
- Development of the SPEAR Model: Separate Phases of Encoding and Retrieval Are Necessary for Storing Multiple Overlapping Associative Memories.Hippocampus · 2025Review
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Spatial memory deficits in Parkinson's disease: neural mechanisms and assessment.American journal of neurodegenerative disease · 2025Review
- Disentangling reference frames in the neural compass.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Levodopa suppresses grid-like activity and impairs spatial learning in novel environments in healthy young adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A goal pointer for a cognitive map in the orbitofrontal cortex.Current opinion in neurobiology · 2023Review
- A Navigation Path Search and Optimization Method for Mobile Robots Based on the Rat Brain's Cognitive Mechanism.Biomimetics (Basel, Switzerland) · 2023Article
- Subgraph Learning for Topological Geolocalization with Graph Neural Networks.Sensors (Basel, Switzerland) · 2023Article
- Learning to predict future locations with internally generated theta sequences.PLoS computational biology · 2023Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A goal-directed navigation model is proposed based on forward linear look-ahead probe of trajectories in a network of head direction cells, grid cells, place cells and prefrontal cortex (PFC) cells. The model allows selection of new goal-directed trajectories. In a novel environment, the virtual rat incrementally creates a map composed of place cells and PFC cells by random exploration. After exploration, the rat retrieves memory of the goal location, picks its next movement direction by forward linear look-ahead probe of trajectories in several candidate directions while stationary in one location, and finds the one activating PFC cells with the highest reward signal. Each probe direction involves activation of a static pattern of head direction cells to drive an interference model of grid cells to update their phases in a specific direction. The updating of grid cell spiking drives place cells along the probed look-ahead trajectory similar to the forward replay during waking seen in place cell recordings. Directions are probed until the look-ahead trajectory activates the reward signal and the corresponding direction is used to guide goal-finding behavior. We report simulation results in several mazes with and without barriers. Navigation with barriers requires a PFC map topology based on the temporal vicinity of visited place cells and a reward signal diffusion process. The interaction of the forward linear look-ahead trajectory probes with the reward diffusion allows discovery of never-before experienced shortcuts towards a goal location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.