ArticleNorth American journal of medical sciences2012
The Reason for Regimen Change Among HIV/AIDS Patients Initiated on First Line Highly Active Antiretroviral Therapy in Southern Ethiopia.
Article in North American journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- First line antiretroviral treatment failure and its association with drug substitution and sex among children in Ethiopia: systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Magnitude and causes of first-line antiretroviral therapy regimen changes among HIV patients in Ethiopia: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2019Pooled it
- Choice of initial antiretroviral drugs and treatment outcomes among HIV-infected patients in sub-Saharan Africa: systematic review and meta-analysis of observational studies.Systematic reviews · 2017Pooled it
- A Bayesian approach for investigating the pharmacogenetics of combination antiretroviral therapy in people with HIV.Biostatistics (Oxford, England) · 2024Article
- Multi-state Markov model for time to treatment changes for HIV/AIDS patients: a retrospective cohort national datasets, Ethiopia.BMC infectious diseases · 2024Article
- Article
- Magnitude and predictors of first-line antiretroviral therapy regimen change among HIV infected adults: A retrospective cross sectional study.Annals of medicine and surgery (2012) · 2022Article
- Pattern of and reasons for antiretroviral therapy regimen change among adult HIV/AIDS patients at regional hospital in Eastern Ethiopia: A 10-year retrospective study.SAGE open medicine · 2019Article
- Modification of Initial Highly Active Antiretroviral Therapy (HAART) Regimen in Paediatric HIV Patients.The open AIDS journal · 2018Article
- Motives for change of first-line antiretroviral therapy regimens in an unselected cohort of HIV/AIDS patients at a major referral centre in South-west Cameroon.BMC research notes · 2017Article
- Multi-state models for the analysis of time-to-treatment modification among HIV patients under highly active antiretroviral therapy in Southwest Ethiopia.BMC infectious diseases · 2017Article
- The incidence of first-line antiretroviral treatment changes and related factors among HIV-infected sex workers in Nairobi, Kenya.The Pan African medical journal · 2017Article
- Clinical analysis of HIV/AIDS patients with drug eruption in Yunnan, China.Scientific reports · 2016Article
- Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana.The Pan African medical journal · 2014Article
- HIV-related neuropathy: current perspectives.HIV/AIDS (Auckland, N.Z.) · 2013Review
- Human immunodeficiency virus - associated lymphomas: a neglected domain.North American journal of medical sciences · 2013Article
- Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHighly active antiretroviral therapy (HAART) has markedly decreased the morbidity and mortality due to HIV disease. However, toxicities, comorbidity, pregnancy, and treatment failure, among others, would result in frequent initial HAART regimen change.
aimThe study was designed to assess the causes of initial highly active antiretroviral therapeutic regimen changes among patients on HAART. MATERIALS AND
methodsThe study was conducted using a retrospective institution-based study, by reviewing the patient information sheet and physician diagnosis cards. Patient cards that showed a change in the initial treatment regimen were assessed and analyzed, to identify the common reason that resulted in a change from the initial treatment regimen. The data was analyzed using SPSS version 16.0.
resultsA total of 340 patient cards were assessed. The majority of the patients (69.29%) were females. The most common first regimen, before the first switch, was stavudine / lamivudine / nevirapine (D4T/3TC/NVP) (54.70%) and stavudine / lamivudine / Efavirenz (D4T/3TC/EFV) (20.88%). The main reasons for modification were toxicity, comorbidity, pregnancy, and treatment failure. The main types of toxicities observed were peripheral neuropathy (36.52%), rash (17.83%), and anemia (17.39%).
conclusionToxicity was the main reason for the modification of initial HAART among the study population. Efavirenz-based regimens had the lowest hazard for change relatively, except in pregnancy-related cases.
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