ArticlePloS one2012
Measuring and estimating GFR and treatment effect in ADPKD patients: results and implications of a longitudinal cohort study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.The New England journal of medicine · 2020Trial
- Trial
- Effect of Sirolimus on Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease and CKD Stages 3b-4.Clinical journal of the American Society of Nephrology : CJASN · 2016Trial
- Trial
- Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study.BMJ (Clinical research ed.) · 2026Article
- Impact of race-based and race-free CKD-EPI equations on estimated glomerular filtration rate in a multicenter retrospective cohort of autosomal dominant polycystic kidney disease.Turkish journal of medical sciences · 2026Article
- Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease: Real practice experience.World journal of nephrology · 2025Article
- Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study.Health technology assessment (Winchester, England) · 2024Article
- Evaluation of kidney disease using e-GFR compared to measured creatinine clearance.Bioinformation · 2024Article
- Estimated GFR in autosomal dominant polycystic kidney disease: errors of an unpredictable method.Journal of nephrology · 2022Article
- A Systematic Review of Reported Outcomes in ADPKD Studies.Kidney international reports · 2022Article
- Relationship between decline in estimated or measured glomerular filtration rate and 16-year postrenal transplant outcome.Clinical kidney journal · 2021Article
- The correlation between kidney volume and measured glomerular filtration rate in an Asian ADPKD population: a prospective cohort study.BMC nephrology · 2021Article
- Somatostatin in renal physiology and autosomal dominant polycystic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors.International journal of obesity (2005) · 2020Article
- Estimated GFR: time for a critical appraisal.Nature reviews. Nephrology · 2019Review
- Metformin in autosomal dominant polycystic kidney disease: experimental hypothesis or clinical fact?BMC nephrology · 2018Article
- Article
- Tolvaptan in the treatment of autosomal dominant polycystic kidney disease: patient selection and special considerations.International journal of nephrology and renovascular disease · 2018Review
- Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trials failed to demonstrate protective effects of investigational treatments on glomerular filtration rate (GFR) reduction in Autosomal Dominant Polycystic Kidney Disease (ADPKD). To assess whether above findings were explained by unreliable GFR estimates, in this academic study we compared GFR values centrally measured by iohexol plasma clearance with corresponding values estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi) and abbreviated Modification of Diet in Renal Disease (aMDRD) formulas in ADPKD patients retrieved from four clinical trials run by a Clinical Research Center and five Nephrology Units in Italy. Measured baseline GFRs and one-year GFR changes averaged 78.6±26.7 and 8.4±10.3 mL/min/1.73 m(2) in 111 and 71 ADPKD patients, respectively. CKD-Epi significantly overestimated and aMDRD underestimated baseline GFRs. Less than half estimates deviated by <10% from measured values. One-year estimated GFR changes did not detect measured changes. Both formulas underestimated GFR changes by 50%. Less than 9% of estimates deviated <10% from measured changes. Extent of deviations even exceeded that of measured one-year GFR changes. In ADPKD, prediction formulas unreliably estimate actual GFR values and fail to detect their changes over time. Direct kidney function measurements by appropriate techniques are needed to adequately evaluate treatment effects in clinics and research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.