ArticlePloS one2012
The imprinted gene DIO3 is a candidate gene for litter size in pigs.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- Effect of SNPs on Litter Size in Swine.Current issues in molecular biology · 2024Article
- Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing.Genome biology · 2023Article
- A Bayesian Multivariate Gametic Model in a Reciprocal Cross with Genomic Information: An Example with Two Iberian Varieties.Animals : an open access journal from MDPI · 2023Article
- Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.BMC biology · 2022Article
- Evaluation of the phenotypic and genomic background of variability based on litter size of Large White pigs.Genetics, selection, evolution : GSE · 2022Article
- Identification of the porcine IG-DMR and abnormal imprinting ofFrontiers in cell and developmental biology · 2022Article
- Genotype-by-environment interactions for reproduction, body composition, and growth traits in maternal-line pigs based on single-step genomic reaction norms.Genetics, selection, evolution : GSE · 2021Article
- Article
- Review
- Hypomethylation in the promoter region ofArchives animal breeding · 2019Article
- Influence of swine leukocyte antigen haplotype on serum antibody titers against swine erysipelas vaccine and reproductive and meat production traits of SLA-defined selectively bred Duroc pigs.The Journal of veterinary medical science · 2018Article
- Association of single-nucleotide polymorphisms inArchives animal breeding · 2018Article
- Use of haplotypes to identify regions harbouring lethal recessive variants in pigs.Genetics, selection, evolution : GSE · 2017Article
- DNA methylation patterns and gene expression associated with litter size in Berkshire pig placenta.PloS one · 2017Article
- Genomic prediction using models with dominance and imprinting effects for backfat thickness and average daily gain in Danish Duroc pigs.Genetics, selection, evolution : GSE · 2016Article
- Genome-wide association analyses using a Bayesian approach for litter size and piglet mortality in Danish Landrace and Yorkshire pigs.BMC genomics · 2016Article
- Incorporating parent-of-origin effects in whole-genome prediction of complex traits.Genetics, selection, evolution : GSE · 2016Article
- A GWAS assessment of the contribution of genomic imprinting to the variation of body mass index in mice.BMC genomics · 2015Article
- Genomic imprinting effects on complex traits in domesticated animal species.Frontiers in genetics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic imprinting is an important epigenetic phenomenon, which on the phenotypic level can be detected by the difference between the two heterozygote classes of a gene. Imprinted genes are important in both the development of the placenta and the embryo, and we hypothesized that imprinted genes might be involved in female fertility traits. We therefore performed an association study for imprinted genes related to female fertility traits in two commercial pig populations. For this purpose, 309 SNPs in fifteen evolutionary conserved imprinted regions were genotyped on 689 and 1050 pigs from the two pig populations. A single SNP association study was used to detect additive, dominant and imprinting effects related to four reproduction traits; total number of piglets born, the number of piglets born alive, the total weight of the piglets born and the total weight of the piglets born alive. Several SNPs showed significant (q-value < 0.10) additive and dominant effects and one SNP showed a significant imprinting effect. The SNP with a significant imprinting effect is closely linked to DIO3, a gene involved in thyroid metabolism. The imprinting effect of this SNP explained approximately 1.6% of the phenotypic variance, which corresponded to approximately 15.5% of the additive genetic variance. In the other population, the imprinting effect of this QTL was not significant (q-value > 0.10), but had a similar effect as in the first population. The results of this study indicate a possible association between the imprinted gene DIO3 and female fertility traits in pigs.
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Registered trials
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