ArticleInternational journal of biological sciences2012
Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.
Article in International journal of biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of potential shared gene signatures between gastric cancer and type 2 diabetes: a data-driven analysis.Frontiers in medicine · 2024Article
- Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer.Current medical science · 2022Article
- Gastric cancer: a comprehensive review of current and future treatment strategies.Cancer metastasis reviews · 2020Review
- Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.Theranostics · 2020Article
- Human renal adipose tissue from normal and tumor kidney: its influence on renal cell carcinoma.Oncotarget · 2019Article
- Evaluation of calcium-binding protein A11 promotes the carcinogenesis of hypopharygeal squamous cell carcinoma via the PI3K/AKT signaling pathway.American journal of translational research · 2019Article
- Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion.Journal of Cancer · 2019Article
- Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers.Journal of Cancer · 2019Article
- Zac1 regulates IL-11 expression in osteoarthritis.Oncotarget · 2018Article
- Identification of hub genes with prognostic values in gastric cancer by bioinformatics analysis.World journal of surgical oncology · 2018Article
- Fibroblast and keratinocyte gene expression following exposure to the extracts of holy basil plant (Data in brief · 2018Article
- Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma.Nature communications · 2018Article
- Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Data in brief · 2018Article
- Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts.Human cell · 2018Article
- Article
- Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.Molecular medicine (Cambridge, Mass.) · 2014Article
- Quantitative proteomics approach to screening of potential diagnostic and therapeutic targets for laryngeal carcinoma.PloS one · 2014Article
- Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers.Cancer science · 2013Review
- S100A11 is a migration-related protein in laryngeal squamous cell carcinoma.International journal of medical sciences · 2013Article
- The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of the invasion and metastasis of cancer; versican is also known to favour the homeostasis of the ECM. Interleukin-11 (IL-11) is an important cytokine that exhibits a wide variety of biological effects in gastric cancer development. Here, we analysed the expression of versican isoforms and found that the major isoforms expressed by both gastric carcinoma tissue and gastric cell lines were V0 and V1, and V1 was significantly higher in gastric carcinoma tissue. The treatment of the gastric cell lines AGS and MKN45 with rhIL-11 resulted in a significant increase in the expression of V0 and V1. Exogenous IL-11 increased migration in AGS and MKN45 cells, whereas these effects were reversed when the expression of V0 and V1 were abolished by siRNA targeting versican V0/V1. Collectively, these findings suggest that the abnormally expressed versican and its isoforms participate, at least in part, in the progress of gastric carcinoma triggered by IL-11.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.