ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Divergent host-pathogen interactions in neurolisteriosis: cytosolic replication vs. phagosomal dormancy of Listeria monocytogenes in CNS macrophages.Acta neuropathologica · 2025Article
- Ischemia/reperfusion-associated oxidative stress is an aggravating factor for pressure ulcers.Journal of clinical biochemistry and nutrition · 2025Article
- Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation inAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Superoxide Radicals in the Execution of Cell Death.Antioxidants (Basel, Switzerland) · 2022Review
- Activation of the TCA Cycle to Provide Immune Protection in Zebrafish Immunized by High Magnesium-PreparedFrontiers in immunology · 2021Article
- Neutrophils: Many Ways to Die.Frontiers in immunology · 2021Review
- Pathologic properties of SOD3 variant R213G in the cardiovascular system through the altered neutrophils function.PloS one · 2020Article
- Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion onPathogens (Basel, Switzerland) · 2019Article
- The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response.Redox biology · 2019Article
- Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia.Journal of the American Heart Association · 2019Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Comparative analysis of seven types of superoxide dismutases for their ability to respond to oxidative stress in Bombyx mori.Scientific reports · 2019Article
- A Comparison of Oral and Intravenous Mouse Models of Listeriosis.Pathogens (Basel, Switzerland) · 2018Review
- Analysis of the Effect of Intestinal Ischemia and Reperfusion on the Rat Neutrophils Proteome.Frontiers in molecular biosciences · 2018Article
- Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream.BMC genomics · 2017Article
- Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver.Infection and immunity · 2016Article
- The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Antioxidant Defenses of Francisella tularensis Modulate Macrophage Function and Production of Proinflammatory Cytokines.The Journal of biological chemistry · 2016Article
- Vaccination of Elk (Cervus canadensis) with Brucella abortus Strain RB51 Overexpressing Superoxide Dismutase and Glycosyltransferase Genes Does Not Induce Adequate Protection against Experimental Brucella abortus Challenge.Frontiers in cellular and infection microbiology · 2016Article
- Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.Journal of bacteriology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Reactive oxygen species and reactive nitrogen species play important roles during immune responses to bacterial pathogens. Extracellular superoxide dismutase (ecSOD) regulates extracellular concentrations of reactive oxygen species and reactive nitrogen species and contributes to tissue protection during inflammatory insults. The participation of ecSOD in immune responses seems therefore intuitive, yet is poorly understood. In the current study, we used mice with varying levels of ecSOD activity to investigate the involvement of this enzyme in immune responses against Listeria monocytogenes. Surprisingly, our data demonstrate that despite enhanced neutrophil recruitment to the liver, ecSOD activity negatively affected host survival and bacterial clearance. Increased ecSOD activity was accompanied by decreased colocalization of neutrophils with bacteria, as well as increased neutrophil apoptosis, which reduced overall and neutrophil-specific TNF-α production. Liver leukocytes from mice lacking ecSOD produced equivalent NO· compared with liver leukocytes from mice expressing ecSOD. However, during infection, there were higher levels of peroxynitrite (NO(3)·(-)) in livers from mice lacking ecSOD compared with livers from mice expressing ecSOD. Neutrophil depletion studies revealed that high levels of ecSOD activity resulted in neutrophils with limited protective capacity, whereas neutrophils from mice lacking ecSOD provided superior protection compared with neutrophils from wild-type mice. Taken together, our data demonstrate that ecSOD activity reduces innate immune responses during bacterial infection and provides a potential target for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.