ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 75 citations in OpenAlex.
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- The 'autoimmunome' of centenarians.Journal of translational autoimmunity · 2025Article
- Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells.Nature communications · 2025Article
- An Exploratory Study for Proteomic-Based Markers of Joint Pain and Chronic Back Pain.European journal of pain (London, England) · 2025Article
- Monocyte Dynamics in Chikungunya Fever: Sustained Activation and Vascular-Coagulation Pathway Involvement.Viruses · 2025Article
- Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling.Scientific reports · 2025Article
- Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases.Journal of bone metabolism · 2025Article
- CeDAR: incorporating cell type hierarchy improves cell type-specific differential analyses in bulk omics data.Genome biology · 2023Article
- A Multiscale Molecular Dynamic Analysis Reveals the Effect of Sialylation on EGFR Clustering in a CRISPR/Cas9-Derived Model.International journal of molecular sciences · 2022Article
- EGFR blocker lapatinib inhibits the synthesis of matrix metalloproteinases from synovial fibroblasts.Turkish journal of medical sciences · 2022Article
- Identification and validation of potential hub genes in rheumatoid arthritis by bioinformatics analysis.American journal of translational research · 2022Article
- Potential mechanism of action of Jing Fang Bai Du San in the treatment of COVID-19 using docking and network pharmacology.International journal of medical sciences · 2022Article
- Macrophage reprogramming for therapy.Immunology · 2021Review
- A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets.Science signaling · 2021Article
- Phenylalanine Is a Novel Marker for Radiographic Knee Osteoarthritis Progression: The MOST Study.The Journal of rheumatology · 2021Article
- Article
- Identification of biomarkers associated with synovitis in rheumatoid arthritis by bioinformatics analyses.Bioscience reports · 2020Observational
- Amphiregulin Aggravates GlomerulonephritisJournal of the American Society of Nephrology : JASN · 2020Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the formation of pannus and the destruction of cartilage and bone in the synovial joints. Although immune cells, which infiltrate the pannus and promote inflammation, play a prominent role in the pathogenesis of RA, other cell types also contribute. Proliferation of synovial fibroblasts, for example, underlies the formation of the pannus, while proliferation of endothelial cells results in neovascularization, which supports the growth of the pannus by supplying it with nutrients and oxygen. The synovial fibroblasts also promote inflammation in the synovium by producing cytokines and chemokines. Finally, osteoclasts cause the destruction of bone. In this study, we show that erlotinib, an inhibitor of the tyrosine kinase epidermal growth factor receptor (EGFR), reduces the severity of established collagen-induced arthritis, a mouse model of RA, and that it does so by targeting synovial fibroblasts, endothelial cells, and osteoclasts. Erlotinib-induced attenuation of autoimmune arthritis was associated with a reduction in number of osteoclasts and blood vessels, and erlotinib inhibited the formation of murine osteoclasts and the proliferation of human endothelial cells in vitro. Erlotinib also inhibited the proliferation and cytokine production of human synovial fibroblasts in vitro. Moreover, EGFR was highly expressed and activated in the synovium of mice with collagen-induced arthritis and patients with RA. Taken together, these findings suggest that EGFR plays a central role in the pathogenesis of RA and that EGFR inhibition may provide benefits in the treatment of RA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.