Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012
Assessing the impact of a cooperative group trial on breast cancer care in the medicare population.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Older women's experience with breast cancer treatment: A systematic review of qualitative literature.Breast (Edinburgh, Scotland) · 2020Pooled it
- The POWER-PAK Score Characterizes Tumor Response to 3 Months of Preoperative Endocrine Therapy.Annals of surgical oncology · 2023Trial
- Trial
- Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Trial
- Downstream Effects of Omission of Axillary Surgery in Older Adults with Early-Stage HR+/HER2- Breast Cancer.Annals of surgical oncology · 2025Article
- How to Optimize Deimplementation of Sentinel Lymph Node Biopsy?The breast journal · 2024Article
- Invasive Breast Cancer Treatment Patterns in Women Age 80 and Over: A Report from the National Cancer Database.Clinical breast cancer · 2022Article
- Effects of Adjuvant Endocrine Therapy Adherence and Radiation on Recurrence and Survival Among Older Women with Early-Stage Breast Cancer.Annals of surgical oncology · 2021Article
- Travel, Treatment Choice, and Survival Among Breast Cancer Patients: A Population-Based Analysis.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Long-term Impact of CALGB 9343 on Radiation Utilization.The Journal of surgical research · 2020Article
- Predicting adjuvant endocrine therapy initiation and adherence among older women with early-stage breast cancer.Breast cancer research and treatment · 2020Article
- Evaluating the Long-Term Impact of a Cooperative Group Trial on Radiation Use and Adjuvant Endocrine Therapy Adherence Among Older Women.Annals of surgical oncology · 2020Article
- Feasibility evaluation of non-invasive cardiac function technology during echocardiography-based cardiac stress testing.Journal of clinical monitoring and computing · 2020Article
- "Radiotherapy for older women (ROW)": A risk calculator for women with early-stage breast cancer.Journal of geriatric oncology · 2020Article
- Does persistent use of radiation in women > 70 years of age with early-stage breast cancer reflect tailored patient-centered care?Breast cancer research and treatment · 2020Article
- Pros and cons of radiotherapy omission in elderly breast cancer patients following breast conservative surgery.Translational cancer research · 2020Review
- Could a Personalized Strategy Using Accelerated Partial Breast Irradiation be an Advantage for Elderly Patients? A Systematic Review of the Literature and Multidisciplinary Opinion.Journal of oncology · 2020Review
- Surgery in the Older Patient with Breast Cancer.Current oncology reports · 2019Review
- Persistent Use of Extended Fractionation Palliative Radiotherapy for Medicare Beneficiaries With Metastatic Breast Cancer, 2011 to 2014.American journal of clinical oncology · 2019Article
- Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose?Annals of surgical oncology · 2019Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe Cancer and Leukemia Group B (CALGB) C9343 trial found that adjuvant radiation therapy (RT) provided minimal benefits for older women with breast cancer. Although treatment guidelines were changed to indicate that some women could forego RT, the impact of the C9343 results on clinical practice is unclear. PATIENTS AND
methodsWe used the Surveillance, Epidemiology, and End Results (SEER) -Medicare data set to assess the use of adjuvant RT in a sample of women ≥ 70 years old diagnosed with stage I breast cancer from 2001 to 2007 who fulfilled the C9343 inclusion criteria. We used log-binomial regression to estimate the relation between publication of C9343 and use of RT in the full sample and across strata of patient and health system characteristics.
resultsOf the 12,925 Medicare beneficiaries in our sample (mean age, 77.7 years), 76.5% received RT. Approximately 79% of women received RT before study publication compared with 75% after (adjusted relative risk of receiving RT postpublication v prepublication: 0.97; 95% CI, 0.95 to 0.98). Although use of RT was lower after the trial within all strata of age and life expectancy, the magnitude of this decrease did not differ significantly by strata. For instance, among patients with life expectancy less than 5 years, RT use decreased by 3.7%, from 44.4% prepublication to 40.7% postpublication. Among patients with life expectancy ≥ 10 years, RT use decreased by 3.0%, from 92.0% to 89.0%.
conclusionThe C9343 trial had minimal impact on the use of RT among older women in the Medicare population, even among the oldest women and those with shorter life expectancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.