ArticleProceedings of the National Academy of Sciences of the United States of America2012
Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoreduplication in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
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- Study on the interaction preference between CYCD subclass and CDK family members at the poplar genome level.Scientific reports · 2022Article
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- The CDK Inhibitor SIAMESE Targets Both CDKA;1 and CDKB1 Complexes to Establish Endoreplication in Trichomes.Plant physiology · 2020Article
- Deconstructing the genetic architecture of iron deficiency chlorosis in soybean using genome-wide approaches.BMC plant biology · 2020Article
- Time-specific and pleiotropic quantitative trait loci coordinately modulate stem growth in Populus.Plant biotechnology journal · 2019Article
- Lineage- and stage-specific expressedDevelopment (Cambridge, England) · 2018Article
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- Association mapping for floral traits in cultivated Paeonia rockii based on SSR markers.Molecular genetics and genomics : MGG · 2017Article
- Non-SMC elements 1 and 3 are required for early embryo and seedling development in Arabidopsis.Journal of experimental botany · 2017Article
- Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphological Traits in Arabidopsis.Plant physiology · 2016Article
- Genotype by watering regime interaction in cultivated tomato: lessons from linkage mapping and gene expression.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
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12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoreduplication is the process where a cell replicates its genome without mitosis and cytokinesis, often followed by cell differentiation. This alternative cell cycle results in various levels of endoploidy, reaching 4× or higher one haploid set of chromosomes. Endoreduplication is found in animals and is widespread in plants, where it plays a major role in cellular differentiation and plant development. Here, we show that variation in endoreduplication between Arabidopsis thaliana accessions Columbia-0 and Kashmir is controlled by two major quantitative trait loci, ENDO-1 and ENDO-2. A local candidate gene association analysis in a set of 87 accessions, combined with expression analysis, identified CYCD5;1 as the most likely candidate gene underlying ENDO-2, operating as a rate-determining factor of endoreduplication. In accordance, both the overexpression and silencing of CYCD5;1 were effective in changing DNA ploidy levels, confirming CYCD5;1 to be a previously undescribed quantitative trait gene underlying endoreduplication in Arabidopsis.
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