ArticleInfection and immunity2012
Development of a contemporary animal model of Candida albicans-associated denture stomatitis using a novel intraoral denture system.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
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- A Denture Use Model Associated withJournal of fungi (Basel, Switzerland) · 2022Article
- Cross-kingdom interaction betweenFrontiers in microbiology · 2022Review
- Development of a novel denture care agent with highly active enzyme, arazyme.BMC oral health · 2021Article
- Antiadhesive Properties of Imidazolium Ionic Liquids Based on (-)-Menthol AgainstInternational journal of molecular sciences · 2021Article
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- A novel acrylic resin palatal device contaminated with Candida albicans biofilm for denture stomatitis induction in Wistar rats.Journal of applied oral science : revista FOB · 2021Article
- Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production.NPJ biofilms and microbiomes · 2020Article
- Histocompatibility of Novel Cycloaliphatic Comonomer in Heat-cured Denture Base Acrylic Resin: Histomorphometric Analysis in Rats.Journal of pharmacy & bioallied sciences · 2020Article
- Candida-Associated Denture Stomatitis and Murine Models: What Is the Importance and Scientific Evidence?Journal of fungi (Basel, Switzerland) · 2020Review
- Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020Review
- Oral Candidiasis: A Disease of Opportunity.Journal of fungi (Basel, Switzerland) · 2020Review
- How Biofilm Growth AffectsFrontiers in microbiology · 2020Review
- Digital Design of a Universal Rat Intraoral Device for Therapeutic Evaluation of a Topical Formulation againstInfection and immunity · 2019Article
- Article
- Impact of frequency of denture cleaning on microbial and clinical parameters - a bench to chairside approach.Journal of oral microbiology · 2019Article
- Methodologies forMicrobial cell (Graz, Austria) · 2018Review
- Development and regulation of single- and multi-species Candida albicans biofilms.Nature reviews. Microbiology · 2018Review
- S. oralis activates the Efg1 filamentation pathway in C. albicans to promote cross-kingdom interactions and mucosal biofilms.Virulence · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Denture stomatitis (DS) is a fungal infection characterized by inflammation of the oral mucosa in direct contact with the denture and affects up to 50% of denture wearers. Despite the prevalence, very little is known about the role of fungal or host factors that contribute to pathogenesis. Recently, we developed a novel intraoral denture system for rodent research. This denture system consists of custom-fitted fixed and removable parts to allow repeated sampling and longitudinal studies. The purpose of this study was to use this denture system to develop a clinically relevant animal model of DS. To establish DS, rats were inoculated with pelleted Candida albicans, which resulted in sustained colonization of the denture and palate for 8 weeks postinoculation. Biofilm formation on the denture was observed by week 4 and on the palate by week 6 postinoculation. Rats were monitored for clinical signs of disease by assigning a clinical score after macroscopic examination of the palate tissue according to Newton's method. By week 4 postinoculation, the majority of inoculated rats with dentures exhibited a clinical score of 1 (pinpoint erythema). By week 6 and week 8 postinoculation, increasing percentages of rats exhibited a clinical score of 2 (diffuse erythema/edema). Histological analysis of palate tissue demonstrated progressively increasing inflammatory cell recruitment throughout the time course of the infection. Palatal biofilm formation was commensurate with development of palatal erythema, which suggests a role for biofilm in the inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.