ArticleMolecular imaging and biology2012
Validity of simplified 3'-deoxy-3'-[18F]fluorothymidine uptake measures for monitoring response to chemotherapy in locally advanced breast cancer.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Repeatability of quantitativeEuropean journal of nuclear medicine and molecular imaging · 2018Pooled it
- Methodological considerations in quantification of 3'-deoxy-3'-[18F]fluorothymidine uptake measured with positron emission tomography in patients with non-small cell lung cancer.Molecular imaging and biology · 2014Trial
- Prospective comparison of early interimBMC cancer · 2021Article
- Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft.EJNMMI research · 2016Article
- Pilot study assessing (18)F-fluorothymidine PET/CT in cervical and vaginal cancers before and after external beam radiation.Gynecologic oncology reports · 2015Article
- ¹⁸F-FLT PET/CT as an imaging tool for early prediction of pathological response in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy: a pilot study.European journal of nuclear medicine and molecular imaging · 2015Article
- Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer.British journal of cancer · 2014Article
- FLT PET-CT in evaluation of treatment response.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India · 2014Review
- Introduction to the analysis of PET data in oncology.Journal of pharmacokinetics and pharmacodynamics · 2013Review
- PET Tracers for Clinical Imaging of Breast Cancer.Journal of oncology · 2012Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePositron emission tomography using 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) has been suggested as a means for monitoring response to chemotherapy. The aim of this study was to evaluate the validity of simplified uptake measures for assessing response to chemotherapy using [(18)F]FLT in locally advanced breast cancer (LABC). PROCEDURES: Fifteen LABC patients underwent dynamic [(18)F]FLT scans both prior to and after the first cycle of chemotherapy with fluorouracil, epirubicin or doxorubicin, and cyclophosphamide. The net uptake rate constant of [(18)F]FLT, K ( i ), determined by non-linear regression (NLR) of an irreversible two-tissue compartment model was used as the gold standard. In addition to Patlak graphical analysis, standardised uptake values (SUV) and tumour-to-whole blood ratio (TBR) were used for analysing [(18)F]FLT data. Correlations and relationships between simplified uptake measures and NLR before and after chemotherapy were assessed using regression analysis.
resultsNo significant differences in both pre- and post-chemotherapy relationships between any of the simplified uptake measures and NLR were found. However, changes in SUV between baseline and post-therapy scans showed a significant negative bias and slope less than one, while TBR did not.
conclusionsIn LABC, TBR instead of SUV may be preferred for monitoring response to chemotherapy with [(18)F]FLT.
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