ReviewArthritis and rheumatism2012
Osteoarthritis: a disease of the joint as an organ.
8 registry-linked trialsAbstract readReview
In one paragraph
Review in Arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 1,640 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,640citing papers in PubMed, 7 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
The Comparison of the Effectiveness of Exercise and Topical Agent Treatments in Knee Osteoarthritis: A Randomized Controlled Trial
Comparison of Commonly Used Treatment Approaches in the Treatment of Gonarthrosis: Platelet-Rich Plasma, Topical Diclofenac, and Exercise
Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis: a Multicenter Randomized, Double-blind, Placebo-controlled Clinical Trial
Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment
Evaluation of Meniscal Extrusion by Dynamic Ultrasonography in Patients With Ostearthritis and Comparison With Magnetic Resonance Imaging Study.
Comparing the Efficacy of Lyophilized Self Growth Factor Versus Platelet-Rich Plasma(PRP) Injection for Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial
Who cites it
1,640 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Evaluating the efficacy of intra-articular human amniotic suspension allografts for knee osteoarthritis management: A systematic review and meta-analysis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Pooled it
- Efficacy and safety of intra-articular mesenchymal stem cell-based therapies in knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.Clinical rheumatology · 2026Pooled it
- Investigating the therapeutic impact of platelet-rich plasma on knee, hip, and traumatic osteoarthritis: a meta-analysis and systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Synovial inflammation and immune-stromal crosstalk in osteoarthritis-related synovial fibroblast research, 2006-2025: a bibliometric analysis.Frontiers in immunology · 2026Pooled it
- From regeneration to immunomodulation: a 20-year global bibliometric analysis of platelet-rich plasma for osteoarthritis.Frontiers in medicine · 2026Pooled it
- Immunometabolic crosstalk in knee osteoarthritis: a bibliometric and translational analysis (2000-2025).Frontiers in immunology · 2026Pooled it
- Non-coding RNA profiles associated with equine osteoarthritis: a systematic review.Frontiers in veterinary science · 2026Pooled it
- Responders vs. non-responders to mesenchymal stromal cells in knee osteoarthritis: Mechanistic correlates of donor cell and patient features.Stem cell reports · 2026Trial
- GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Trial
- Effects of orally administered cetylated fatty acids on symptoms and functional capacity in patients with knee osteoarthritis: results of a randomized, double-blind, placebo-controlled study.European journal of clinical nutrition · 2025Trial
- Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis.Bioactive materials · 2027Article
- Cultural practices and knee osteoarthritis in Central Asia: a case-control study on risk and protective factors.Future science OA · 2026Article
- Research progress of mesenchymal stem cells/stromal cells and their derivatives against cell senescence in the treatment of osteoarthritis.Annals of medicine · 2026Review
- Multifunctional hydrogel scaffolds for endogenous osteochondral regeneration.Regenerative therapy · 2026Review
- Osteoarthritis and fibroblast activation: an imaging study assessing feasibility and reliability of whole-bodySkeletal radiology · 2026Article
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- SHIP2 deletion in cartilage does not modulate osteoarthritis in male mice.Osteoarthritis and cartilage open · 2026Article
- In situ-built chemo-electroactive hydrogel incorporating Mg-based hydrogen generators for osteoarthritis therapy.Materials today. Bio · 2026Article
- Mitochondrial Communication Networks in the Bone Microenvironment: From the Maintenance of Homeostasis to Translational Interventions for Bone Diseases.Stem cell reviews and reports · 2026Review
- Systematic evidence analysis of symptom modification in hip osteoarthritis following MSC-based interventions.Wiener klinische Wochenschrift · 2026Review
1,580 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Richard F LoeserWake Forest University School of Medicine, Winston-Salem, NC, USA. rloeser@wakehealth.edu
Steven R Goldring
Carla R Scanzello
Mary B Goldring
Funding
Defining Common Molecular Parameters For Onset and Progression of OsteoarthritisRC4AR060546 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B, LI, YEFU · 2010 to 2010
$4.1MIntegrin Function in CartilageR37AR049003 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOESER, RICHARD F · 2012 to 2021
$4.1MRole of ESE1 Regulation of Type II Collagen in CartilageR01AG022021 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B · 2002 to 2014
$3.4MIntegrin Function in CartilageR01AR049003 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOESER, RICHARD F · 2002 to 2011
$2.8MAging and IGF-I in CartilageR01AG016697 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOESER, RICHARD F · 2001 to 2009
$2.4MThe Toll-like receptor pathway in Meniscal Injury and OsteoarthritisK08AR057859 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SCANZELLO, CARLA ROSE · 2010 to 2014
$620kESE 1 a novel transcriptional regulator of cartilage remodelingR56AG022021 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B · 2009 to 2009
$438kNIAMS NIH HHS AR-060546NIAMS NIH HHS AR-49003NIAMS NIH HHS K08 AR057859NIAMS NIH HHS K08-AR-057859NIAMS NIH HHS R01 AR049003NIAMS NIH HHS R37 AR049003NIAMS NIH HHS RC4 AR060546NIA NIH HHS AG-022021NIA NIH HHS AG-16697NIA NIH HHS R01 AG016697NIA NIH HHS R01 AG022021NIA NIH HHS R56 AG022021
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cartilage, ArticularHumansInflammationJointsOsteoarthritis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT02722772ClinicalTrials.gov
NCT02722811ClinicalTrials.gov
NCT05827003ClinicalTrials.gov
NCT05877027ClinicalTrials.gov
NCT05975957ClinicalTrials.gov
NCT05986513ClinicalTrials.gov
and 2 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.