ReviewCurrent neurology and neuroscience reports2012
Disorders of the optic nerve in mitochondrial cytopathies: new ideas on pathogenesis and therapeutic targets.
Review in Current neurology and neuroscience reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The Retina in Patients With Triple A Syndrome: A Window Into Neurodegeneration?Frontiers in endocrinology · 2021Trial
- The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina.Scientific reports · 2026Article
- Leber's hereditary optic neuropathy plus dystonia caused by the mitochondrial ND1 gene m.4160 T > C mutation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Optic Neuritis due to Use of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Case Report.Noro psikiyatri arsivi · 2022Article
- Retinal single-layer analysis with optical coherence tomography shows inner retinal layer thinning in Huntington's disease as a potential biomarker.International ophthalmology · 2019Article
- X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner.Acta neuropathologica communications · 2016Article
- Optical coherence tomography findings in Huntington's disease: a potential biomarker of disease progression.Journal of neurology · 2015Article
- Ophthalmic manifestations of inherited neurodegenerative disorders.Nature reviews. Neurology · 2014Review
- Treatment strategies for inherited optic neuropathies: past, present and future.Eye (London, England) · 2014Review
- Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency.Human molecular genetics · 2013Article
- Neuromuscular and systemic presentations in adults: diagnoses beyond MERRF and MELAS.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
- Treatment of hereditary optic neuropathies.Nature reviews. Neurology · 2012Review
- A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired Forms.Journal of optometryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial cytopathies are a heterogeneous group of human disorders triggered by disturbed mitochondrial function. This can be due to primary mitochondrial DNA mutations or nuclear defects affecting key components of the mitochondrial machinery. Optic neuropathy is a frequent disease manifestation and the degree of visual failure can be profound, with a severe impact on the patient's quality of life. This review focuses on the major mitochondrial disorders exhibiting optic nerve involvement, either as the defining clinical feature or as an additional component of a more extensive phenotype. Over the past decade, significant progress has been achieved in our basic understanding of Leber hereditary optic neuropathy and autosomal-dominant optic atrophy--the two classical paradigms for these mitochondrial optic neuropathies. There are currently limited treatments for these blinding ocular disorders and, ultimately, the aim is to translate these major advances into tangible benefits for patients and their families.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.