ReviewCurrent cardiology reports2012
The role of renal denervation in the treatment of heart failure.
Review in Current cardiology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Renal Artery Denervation in Patients With Chronic Heart Failure Compared With Sham Procedure
A Randomised Controlled Trial Investigating the Effect of Transcatheter Renal Sympathetic Denervation on Symptoms and Cardiac Function in Patients With Heart Failure With Preserved Ejection Fraction.
Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
- Cardiorenal Syndrome and Autonomic Overactivity.Biomedicines · 2025Review
- The denervation or activation of renal sympathetic nerve and renal blood flow.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys.Circulation research · 2022Review
- Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors.International journal of nephrology · 2022Review
- GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation.Cardiovascular diabetology · 2020Article
- Renal denervation improves sodium excretion in rats with chronic heart failure: effects on expression of renal ENaC and AQP2.American journal of physiology. Heart and circulatory physiology · 2019Article
- Cardiac autonomic innervation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Reconsidering Renal Sympathetic Denervation for Heart Failure.JACC. Basic to translational science · 2017Article
- Estimated Glomerular Filtration Rate and 6-Minute Walk Distance in African Americans with Mild to Moderate Heart Failure.Cardiorenal medicine · 2017Article
- Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow.Autonomic neuroscience : basic & clinical · 2017Review
- Neurohormonal Blockade in Heart Failure.Cardiac failure review · 2017Article
- Renal Denervation for Chronic Heart Failure: Background and Pathophysiological Rationale.Korean circulation journal · 2017Review
- Renal denervation improves cardiac function in rats with chronic heart failure: Effects on expression of β-adrenoceptors.American journal of physiology. Heart and circulatory physiology · 2016Article
- Device-Based Therapy for Drug-Resistant Hypertension: An Update.Current hypertension reports · 2016Review
- Renal denervation for resistant hypertension: yes.Internal and emergency medicine · 2016Article
- Cardio-renal syndrome.F1000Research · 2016Review
- A perspective on sympathetic renal denervation in chronic congestive heart failure.Heart failure reviews · 2016Review
- Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy.Scientific reports · 2015Article
- Cardiac innervation and sudden cardiac death.Circulation research · 2015Review
- Activation of afferent renal nerves modulates RVLM-projecting PVN neurons.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
Abstract
The heart and kidney interact in terms of hemodynamics and neurohumoral regulatory mechanisms, and this helps to maintain circulatory homeostasis under normal conditions. However, the normal regulatory mechanisms become inappropriate in the setting of congestive heart failure (CHF), and significant renal dysfunction often develops in CHF patients. Activation of renal sympathetic efferent nerves causes renin release, sodium and water retention, and reduced renal blood flow, all hallmarks of the renal manifestations of CHF. An increase in plasma levels of angiotensin II that is mediated in part by renal sympathetic activation has an effect on the central nervous system to further increase global sympathetic tone. Renal sympathetic activity can be assessed clinically by renal norepinephrine spillover, and an increase in renal norepinephrine spillover in CHF predicts reduced survival. In addition to efferent sympathetic activation, activation of renal sensory nerves in CHF may cause a reflex increase in sympathetic tone that contributes to elevated peripheral vascular resistance and vascular remodeling as well as left ventricular remodeling and dysfunction. In animal models of heart failure, surgical renal denervation has been shown to improve both renal and ventricular function. Although surgical renal denervation has long been known to lower blood pressure and improve survival in patients with hypertension, the invasive nature of this approach and its associated complications has limited its appeal. However, a novel catheter-based device has recently been introduced that specifically interrupts both efferent and afferent renal nerves, and there is significant interest in the use of this device to treat both hypertension and CHF. Several ongoing clinical trials are investigating the safety and efficacy of renal denervation in patients with CHF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.