Evidence map›Paper›PMID 22392172›Full record

Trial reportPediatrics2012

Clinic-integrated behavioral intervention for families of youth with type 1 diabetes: randomized clinical trial.

Tonja R Nansel, Ronald J Iannotti, Aiyi Liu

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 10 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 10 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tonja R NanselEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. nanselt@mail.nih.gov
Ronald J Iannotti
Aiyi Liu
Eunice Kennedy Shriver National Institute of Child Health and Human Development · US

Funding

Statistical Methods for Evaluation of BiomarkersZIAHD008875 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LIU, AIYI · 2009 to 2025
$3.8M
Ca2+ OSCILLATIONS AND KINASES REGULATE EGG ACTIVATIONR01HD043363 · NICHD · TUFTS MEDICAL CENTER · PI DUCIBELLA, THOMAS W · 2003 to 2006
$1.2M
Research On Family Management Of Childhood DiseaseZIAHD008741 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI NANSEL, TONJA · 2009 to 2022
$1.1M
FAMILY MANAGEMENT OF CHILDHOOD DIABETES /TYPE 1/: COORDINATING CENTER-275033360N01HD033360 · NICHD · JAMES BELL ASSOCIATES, INC. · PI MCDONNELL, CHERYL D · 2003 to 2006
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Intramural NIH HHSNICHD NIH HHS N01-HD-3-3360NICHD NIH HHS N01-HD-4-3361NICHD NIH HHS N01-HD-4-3362NICHD NIH HHS N01-HD-4-3363NICHD NIH HHS N01-HD-4-3364
6 · The paper itself

Abstract

objectiveTo test the effect on diabetes management outcomes of a low-intensity, clinic-integrated behavioral intervention for families of youth with type 1 diabetes.

methodsFamilies (n = 390) obtaining care for type 1 diabetes participated in a 2-year randomized clinical trial of a clinic-integrated behavioral intervention designed to improve family diabetes management practices. Measurement of hemoglobin A1c, the primary outcome, was obtained at each clinic visit and analyzed centrally. Blood glucose meter data were downloaded at each visit. Adherence was assessed by using a semistructured interview at baseline, mid-study, and follow-up. Analyses included 2-sample t tests at predefined time intervals and mixed-effect linear-quadratic models to assess for difference in change in outcomes across the study duration.

resultsA significant overall intervention effect on change in glycemic control from baseline was observed at the 24-month interval (P = .03). The mixed-effect model showed a significant intervention by age interaction (P < .001). Among participants aged 12 to 14, a significant effect on glycemic control was observed (P = .009 for change from baseline to 24-month interval; P = .035 for mixed-effect model across study duration), but there was no effect among those aged 9 to 11. There was no intervention effect on child or parent report of adherence; however, associations of change in adherence with change in glycemic control were weak.

conclusionsThis clinic-integrated behavioral intervention was effective in preventing the deterioration in glycemic control evident during adolescence, offering a potential model for integrating medical and behavioral sciences in clinical care.

Indexed as

Adolescent BehaviorChild BehaviorFamilyAdolescentBehavior TherapyChildDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlycated HemoglobinGuideline AdherenceHumansMaleRetrospective StudiesSurveys and QuestionnairesTreatment OutcomeGlycated Hemoglobin

Identifiers

PMID22392172
PMCPMC3313642
OpenAlexW2108510926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.