ArticleJournal of molecular neuroscience : MN2012
Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Evaluation of inflammatory cytokines in drug-naïve major depressive disorder: A systematic review and meta-analysis.International journal of immunopathology and pharmacologyPooled it
- Narrative Review "Dual Frontiers in Neurodegeneration: Pharmacological Synergies and Divergences in Parkinson's Disease and Type 2 Diabetes Mellitus".Cellular and molecular neurobiology · 2026Review
- Monomeric C-reactive Protein Exacerbates Neuronal Injury and Enhances Microglial Activation after Global Cerebral Ischemia in Mice.Molecular neurobiology · 2025Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Visceral adiposity, inflammation, and hippocampal function in obesity.Neuropharmacology · 2022Review
- Role and Perspectives of Inflammation and C-Reactive Protein (CRP) in Psychosis: An Economic and Widespread Tool for Assessing the Disease.International journal of molecular sciences · 2021Review
- Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline.The Journal of clinical endocrinology and metabolism · 2021Observational
- Brain Innate Immune Response in Diet-Induced Obesity as a Paradigm for Metabolic Influence on Inflammatory Signaling.Frontiers in neuroscience · 2019Review
- The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction.Metabolic brain disease · 2018Review
- Association between C-reactive protein and risk of schizophrenia: An updated meta-analysis.Oncotarget · 2017Article
- High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia.Acta neuropathologica · 2016Article
- Differentiating the Influences of Aging and Adiposity on Brain Weights, Levels of Serum and Brain Cytokines, Gastrointestinal Hormones, and Amyloid Precursor Protein.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Fat sensing and metabolic syndrome.Reviews in endocrine & metabolic disorders · 2014Review
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.Brain, behavior, and immunity · 2013Article
- Metabolic disturbances connecting obesity and depression.Frontiers in neuroscience · 2013Review
- Saturable leptin transport across the BBB persists in EAE mice.Journal of molecular neuroscience : MN · 2013Article
- Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis.Journal of molecular neuroscience : MN · 2013Article
- Dietary components in the development of leptin resistance.Advances in nutrition (Bethesda, Md.) · 2013Review
- Emerging role of glial cells in the control of body weight.Molecular metabolism · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Reactive gliosis, a sign of neuroinflammation, has been observed in mice with adult-onset obesity as well as CNS injury. The hypothesis that obesity-derived metabolic factors exacerbate reactive gliosis in response to mechanical injury was tested here on cultured primary glial cells subjected to a well-established model of scratch wound injury. Cells treated with serum from mice with diet-induced obesity (DIO) showed higher immunoreactivity of CD11b (marker for microglia) and GFAP (marker for astrocytes), with morphological changes at both the injury border and areas away from the injury. The effect of DIO serum was greater than that of scratch injury alone. Leptin was almost as effective as DIO serum in inducing microgliosis and astrogliosis in a dose-response manner. By contrast, C-reactive protein (CRP) mainly induced microgliosis in noninjured cells; injury-induced factors appeared to attenuate this effect. The effect of CRP also differed from the effect of the antibiotic minocycline. Minocycline attenuated the microgliosis and to a lesser extent astrogliosis, particularly in CRP-treated cells, thus serving as a negative control. We conclude that blood-borne proinflammatory metabolic factors in obesity increase reactive gliosis and probably exacerbate CNS injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.