ReviewImmunologic research2012
The response of human dendritic cells to co-ligation of pattern-recognition receptors.
Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- CD4Frontiers in immunology · 2026Review
- Immune Modulation with Nanodiscs: Surface Charge Dictates Cellular Interactions and Activation of Macrophages and Dendritic-like Cells.International journal of molecular sciences · 2025Article
- Review
- Isatidis Folium Represses Dextran Sulfate Sodium-Induced Colitis and Suppresses the Inflammatory Response by Inhibiting Inflammasome Activation.Nutrients · 2024Article
- Potential role of immune cell therapy in gynecological cancer and future promises: a comprehensive review.Medical oncology (Northwood, London, England) · 2024Review
- Lipoteichoic acid ofFrontiers in immunology · 2023Article
- Probiotics and Trained Immunity.Biomolecules · 2021Review
- Thapsigargin-Stimulated LAD2 Human Mast Cell Line Is a Potent Cellular Adjuvant for the Maturation of Monocyte-Derived Dendritic Cells for Adoptive Cellular Immunotherapy.International journal of molecular sciences · 2021Article
- A chitosan-based nanosystem as pneumococcal vaccine delivery platform.Drug delivery and translational research · 2021Article
- The role of vitamin A and vitamin D in modulation of the immune response with a focus on innate lymphoid cells.Central-European journal of immunology · 2021Review
- Review
- Dendritic cell engineering for selective targeting of female reproductive tract cancers.The Indian journal of medical research · 2018Review
- Induction of antitumor cytotoxic lymphocytes using engineered human primary blood dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Precision medicine for hepatocelluar carcinoma using molecular pattern diagnostics: results from a preclinical pilot study.Cell death & disease · 2017Article
- Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells.Scientific reports · 2016Article
- Immune Cells and Inflammation in Diabetic Nephropathy.Journal of diabetes research · 2016Review
- Do We Need Worms to Promote Immune Health?Clinical reviews in allergy & immunology · 2015Review
- NLRP3 inflammasome and its inhibitors: a review.Frontiers in pharmacology · 2015Review
- Innate immunity in disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014Review
- Monitoring the initiation and kinetics of human dendritic cell-induced polarization of autologous naive CD4+ T cells.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are key antigen-presenting cells that express a wide variety of pattern-recognition receptors (PRRs). Triggering of a single PRR, especially Toll-like receptors (TLRs) and C-type lectins, induces maturation of DCs, but cooperativity between multiple PRRs is needed in order to achieve an effective immune response. In this review, we summarize the published data related to the effect of individual and joint PRR agonists on DCs and Langerhans-like cells derived from monocytes (MoDCs and MoLCs, respectively). Our results demonstrate that MoDCs co-stimulated with TLR3/TLR7 and TLR3/Dectin-1 ligands induced superior T helper (Th)1 and Th17 immune responses, compared to effects of single agonists. The opposite outcome was observed after co-ligation of TLR3 and Langerin on MoLCs. These findings may be relevant to improve strategy for tumor immunotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.