ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Comparison of HbA1c and oral glucose tolerance test for diagnosis of diabetes in patients with coronary artery disease.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Trends in diabetes incidence in Austria 2013-2017.Scientific reports · 2023Article
- Observational
- Thanatochemical Study of Glycated Hemoglobin in Diabetic Status Assessment.Medicina (Kaunas, Lithuania) · 2021Article
- The Impact of Prediabetes on Two-Year Clinical Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention.Yonsei medical journal · 2018Article
- Correlation Between Pigment Epithelium-Derived Factor (PEDF) level and Degree of Coronary Angiography and Severity of Coronary Artery Disease in a Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults with and without Type 2 Diabetes.Journal of diabetes research · 2017Article
- PERFORMANCE OF A1C VERSUS OGTT FOR THE DIAGNOSIS OF PREDIABETES IN A COMMUNITY-BASED SCREENING.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2016Article
- The association of hemoglobin A1c and high risk plaque and plaque extent assessed by coronary computed tomography angiography.The international journal of cardiovascular imaging · 2016Article
- Risk prediction with triglycerides in patients with stable coronary disease on statin treatment.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Observational
- Article
- Admission glucose, fasting glucose, HbA1c levels and the SYNTAX score in non-diabetic patients undergoing coronary angiography.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Impact of type 2 diabetes mellitus and glucose control on fractional flow reserve measurements in intermediate grade coronary lesions.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Observational
- Tools for practice: screening and diagnosis of type 2 diabetes with HbA1c.Canadian family physician Medecin de famille canadien · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeasurement of glycated hemoglobin A1c (HbA1c) to diagnose diabetes mellitus (DM-2) is recommended by several expert groups. DM-2 occurs very frequently among patients with coronary artery disease (CAD). Therefore, we aimed to investigate the diagnostic strengths of HbA1c and oral glucose tolerance test (OGTT) in detecting latent glucometabolic disturbances among patients with CAD. MATERIALS AND
methodsOne hundred ninety-nine consecutive patients admitted with CAD were included in this observational study. Fasting plasma glucose as well as HbA1c measurement was performed in all study participants and those without preexisting DM-2 underwent an OGTT.
resultsPatients were subdivided according to their medical history into those with previous DM-2 (n = 37). The remaining 162 patients underwent OGTT, which revealed 39 patients with diabetes (DM-(OGTT)), 35 with impaired glucose tolerance (IGT), 20 with impaired fasting glucose (IFG) and 68 with normal glucose tolerance (NGT). Using HbA1c resulted in 6.8% DM and 45.6% at risk (HbA1c 5.7-6.4%) diagnosis. OGTT identified 24.1% DM (p = 0.002 compared with HbA1c) and 21.6% IGT patients. Among those with intermediate HbA1c (5.7-6.4%) 26.5% patients were NGT and only 30.9% displayed DM-2 by use of OGTT. Among patients with HbA1c of <5.7%, 44% (n = 31) of patients had disturbed glucose metabolism. Using receiver-operating curve HbA1c cutoff with the highest sensitivity and specificity was found to be 5.8%. DISCUSSION: There is a large discordance between OGTT and HbA1c in terms of detecting latent DM-2 in patients with CAD. Measurement of HbA1c could result in lower propensity of DM-2 diagnosis.
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