ArticleInternational journal of obesity (2005)2013
Ethnic differentiation of copy number variation on chromosome 16p12.3 for association with obesity phenotypes in European and Chinese populations.
Article in International journal of obesity (2005), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
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- Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome.Molecular biology reports · 2017Article
- Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits.International journal of obesity (2005) · 2016Article
- Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity.European journal of human genetics : EJHG · 2015Article
- Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.Human genetics · 2015Review
- A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.Journal of obesity · 2015Article
- Etiology of Obesity Over the Life Span: Ecological and Genetic Highlights from Asian Countries.Current obesity reports · 2014Article
- Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study.The Journal of clinical endocrinology and metabolism · 2013Article
- Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.Psychosomatic medicineArticle
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveGenomic copy number variations (CNVs) have been strongly implicated as important genetic factors for obesity. A recent genome-wide association study identified a novel variant, rs12444979, which is in high linkage disequilibrium with CNV 16p12.3, for association with obesity in Europeans. The aim of this study was to directly examine the relationship between the CNV 16p12.3 and obesity phenotypes, including body mass index (BMI) and body fat mass. SUBJECTS: Subjects were a multi-ethnic sample, including 2286 unrelated subjects from a European population and 1627 unrelated Han subjects from a Chinese population. Body fat mass was measured using dual energy X-ray absorptiometry.
resultsUsing Affymetrix Genome-Wide Human SNP Array 6.0, we directly detected CNV 16p12.3, with the deletion frequency of 27.26 and 0.8% in the European and Chinese populations, respectively. We confirmed the significant association between this CNV and obesity (BMI: P=1.38 × 10(-2); body fat mass: P=2.13 × 10(-3)) in the European population. Less copy numbers were associated with lower BMI and body fat mass, and the effect size was estimated to be 0.62 (BMI) and 1.41 (body fat mass), respectively. However, for the Chinese population, we did not observe significant association signal, and the frequencies of this deletion CNV are quite different between the European and Chinese populations (P<0.001).
conclusionOur findings first suggest that CNV 16p12.3 might be ethnic specific and cause ethnic phenotypic diversity, which may provide some new clues into the understanding of the genetic architecture of obesity.
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