ReviewInternational journal of obesity (2005)2013
Role of orexin receptors in obesity: from cellular to behavioral evidence.
Review in International journal of obesity (2005), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Reduced plasma interleukin-6 concentration after transcranial direct current stimulation to the prefrontal cortex.Behavioural brain research · 2024Trial
- Crosstalk between alcohol use disorder and obesity: two sides of the same coin?Molecular psychiatry · 2025Review
- Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use.Molecular psychiatry · 2025Article
- Transcutaneous auricular vagus nerve stimulation inhibits food intake and body weight gain through the orexin dependent pathway in high fat diet mice.Scientific reports · 2025Article
- The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress.Biomedicines · 2024Review
- Physiological Role of Orexinergic System for Health.International journal of environmental research and public health · 2022Review
- Orexin, serotonin, and energy balance.WIREs mechanisms of disease · 2022Review
- Structure-based development of a subtype-selective orexin 1 receptor antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reactive oxygen species and male reproductive hormones.Reproductive biology and endocrinology : RB&E · 2018Review
- Spontaneous Physical Activity Defends Against Obesity.Current obesity reports · 2017Review
- Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity.PloS one · 2017Article
- Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice.PloS one · 2017Article
- Neuroinflammatory and autonomic mechanisms in diabetes and hypertension.American journal of physiology. Endocrinology and metabolism · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The orexin peptides and their two receptors are involved in multiple physiological processes, including energy homeostasis, arousal, stress and reward. Higher signaling of the orexin peptides at the orexin receptors (OXR) protects against obesity, but it is less clear how their activation in different brain regions contributes to this behavioral output. This review summarizes the evidence available for a role of central OXR in energy homeostasis and their contribution to obesity. A detailed analysis of anatomical, cellular and behavioral evidence shows that modulation of energy homeostasis by the OXR is largely dependent upon anatomical and cellular context. It also shows that obesity resistance provided by activation of the OXR is distributed across multiple brain sites with site-specific actions. We suggest that understanding the role of the OXR in the development of obesity requires considering both specific mechanisms within brain regions and interactions of orexinergic input between multiple sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.