ArticleMolecules (Basel, Switzerland)2012
A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- An Alternative Method for the Selective Synthesis ofCurrent organic synthesis · 2025Article
- A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Microwave irradiation: a green approach for the synthesis of functionalizedRSC advances · 2018Article
- Lewis acid catalysis and Green oxidations: sequential tandem oxidation processes induced by Mn-hyperaccumulating plants.Environmental science and pollution research international · 2015Article
- An expeditious green route toward 2-aryl-4-phenyl-1H-imidazoles.Organic and medicinal chemistry letters · 2014Article
- One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor.Beilstein journal of organic chemistry · 2013Article
- An expeditious iodine-catalyzed synthesis of 3-pyrrole-substituted 2-azetidinones.Molecules (Basel, Switzerland) · 2012Article
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3 authors.
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Abstract
The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
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