ArticleAntimicrobial agents and chemotherapy2012
Recurrent episodes of candidemia due to Candida glabrata with a mutation in hot spot 1 of the FKS2 gene developed after prolonged therapy with caspofungin.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Recurrent Candidemia: Trends and Risk Factors Among Persons Residing in 4 US States, 2011-2018.Open forum infectious diseases · 2022Article
- Article
- Molecular Typing of Candida glabrata.Mycopathologia · 2020Review
- Inflammatory Cell Recruitment inJournal of clinical medicine · 2019Article
- Clinical and Laboratory Development of Echinocandin Resistance inFrontiers in microbiology · 2019Article
- Rapid emergence ofMedical mycology case reports · 2017Article
- Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor.G3 (Bethesda, Md.) · 2016Article
- Biofilm Production and Antibiofilm Activity of Echinocandins and Liposomal Amphotericin B in Echinocandin-Resistant Yeast Species.Antimicrobial agents and chemotherapy · 2016Article
- Rapid development of Candida krusei echinocandin resistance during caspofungin therapy.Antimicrobial agents and chemotherapy · 2015Article
- Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.Antimicrobial agents and chemotherapy · 2014Article
- Assessment of caspofungin susceptibility of Candida glabrata by the Etest®, CLSI, and EUCAST methods, and detection of FKS1 and FKS2 mutations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Echinocandin failure case due to a previously unreported FKS1 mutation in Candida krusei.Antimicrobial agents and chemotherapy · 2014Article
- Use of micafungin as a surrogate marker to predict susceptibility and resistance to caspofungin among 3,764 clinical isolates of Candida by use of CLSI methods and interpretive criteria.Journal of clinical microbiology · 2014Article
- Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011.Antimicrobial agents and chemotherapy · 2014Article
- Comparison between the EUCAST procedure and the Etest for determination of the susceptibility of Candida species isolates to micafungin.Antimicrobial agents and chemotherapy · 2013Article
- Article
- Stepwise development of a homozygous S80P substitution in Fks1p, conferring echinocandin resistance in Candida tropicalis.Antimicrobial agents and chemotherapy · 2013Article
- Evaluation of caspofungin susceptibility testing by the new Vitek 2 AST-YS06 yeast card using a unique collection of FKS wild-type and hot spot mutant isolates, including the five most common candida species.Antimicrobial agents and chemotherapy · 2013Article
- Comparison of dimethyl sulfoxide and water as solvents for echinocandin susceptibility testing by the EUCAST methodology.Journal of clinical microbiology · 2012Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery. In the first episode of candidemia, an echinocandin-susceptible Candida glabrata strain was isolated, and the patient was treated with caspofungin. The isolates from the later episodes showed resistance to echinocandins. Analysis of the HS1 region of the FKS2 gene showed the amino acid substitution S663P. Microsatellite analysis demonstrated a strong genetic relationship between the isolates.
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