ReviewJournal of dermatological science2012
Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia.
Review in Journal of dermatological science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 67 citations in OpenAlex.
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- Advances in Protein and Polypeptide Drug Analytics.Current pharmaceutical design · 2026Review
- Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging.Journal of advanced research · 2025Article
- Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X.Brazilian journal of veterinary medicine · 2025Article
- Three-dimensional cell culture using CD9-positive cells isolated from marginal cell layer of intermediate lobe of rats sustains in vivo-like primary niche environment.The Journal of reproduction and development · 2024Article
- Vitamin A in Skin and Hair: An Update.Nutrients · 2022Review
- Regulation and dysregulation of hair regeneration: aiming for clinical application.Cell regeneration (London, England) · 2022Review
- Genomic and Transcriptomic Characterization of Atypical Recurrent Flank Alopecia in the Cesky Fousek.Genes · 2022Article
- Localization of putative pituitary stem/progenitor cells in female dairy cattle.The Journal of veterinary medical science · 2021Article
- Dietary Vitamin A Impacts Refractory Telogen.Frontiers in cell and developmental biology · 2021Article
- Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging.Frontiers in cell and developmental biology · 2021Article
- Its written all over your face: The molecular and physiological consequences of aging skin.Mechanisms of ageing and development · 2020Review
- Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep.Animals : an open access journal from MDPI · 2020Article
- Mechanical stretch induces hair regeneration through the alternative activation of macrophages.Nature communications · 2019Article
- Exposure to 50 Hz electromagnetic fields enhances hair follicle regrowth in C57BL/6 mice.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles.Cell communication and signaling : CCS · 2019Article
- Article
- Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules.Development, growth & differentiation · 2019Article
- External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Isolation and characterisation of CD9-positive pituitary adult stem/progenitor cells in rats.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the "stem cell niche". However, recent studies reveal that there can be multiple layers of environmental controls. Here we review these environmental controls using the paradigm of hair stem cells, because to observe and analyze the growth of hair is easier due to their characteristic cyclic regeneration pattern. The length of hair fibers is regulated by the duration of the growth period. In the hair follicles, hair stem cells located in the follicle bulge interact with signals from the dermal papilla. Outside of the follicle, activation of hair stem cells has been shown to be modulated by molecules released from the intra-dermal adipose tissue as well as body hormone status, immune function, neural activities, and aging. The general physiological status of an individual is further influenced by circadian rhythms and changing seasons. The interactive networks of these environmental factors provide new understanding on how stem cell homeostasis is regulated, inspiring new insights for regenerative medicine. Therapies do not necessarily have to be achieved by using stem cells themselves which may constitute a higher risk but by modulating stem cell activity through targeting one or multiple layers of their micro- and macro-environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.