The cyclin K/Cdk12 complex: an emerging new player in the maintenance of genome stability.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Absence of synergistic effects by CDK12/13 inhibition in combination with cisplatin or olaparib in ovarian cancer cells.Scientific reports · 2026
   Article
2. Targeting CDK9 for Anti-Cancer Therapeutics.Cancers · 2021
   Review
3. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.EMBO reports · 2019
   Article
4. Quantitative Mass Spectrometry to Interrogate Proteomic Heterogeneity in Metastatic Lung Adenocarcinoma and Validate a Novel Somatic Mutation CDK12-G879V.Molecular & cellular proteomics : MCP · 2019
   Article
5. The Ethnic-Specific Spectrum of Germline Nucleotide Variants in DNA Damage Response and Repair Genes in Hereditary Breast and Ovarian Cancer Patients of Tatar Descent.Frontiers in oncology · 2018
   Article
6. CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.PloS one · 2016
   Article
7. Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.Biochimica et biophysica acta · 2015
   Article
8. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.Nucleic acids research · 2015
   Article
9. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Oncogene · 2014
   Article
10. Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.The Journal of biological chemistry · 2014
    Article
11. Regulation of CDK9 activity by phosphorylation and dephosphorylation.BioMed research international · 2014
    Review
12. Lost in transcription: molecular mechanisms that control HIV latency.Viruses · 2013
    Review
13. Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage.Cell cycle (Georgetown, Tex.) · 2013
    Article
14. Cyclin K goes with Cdk12 and Cdk13.Cell division · 2012
    Article

Corrections and comments

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  The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.2011

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.