ArticleDevelopmental biology2012
Combinatorial use of translational co-factors for cell type-specific regulation during neuronal morphogenesis in Drosophila.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Roles for the RNA-Binding Protein Caper in Reproductive Output inJournal of developmental biology · 2022Article
- Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression inLife (Basel, Switzerland) · 2021Article
- Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling.Nature communications · 2021Article
- The Role of Dynamic miRISC During Neuronal Development.Frontiers in molecular biosciences · 2020Review
- The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors.Bioscience reports · 2019Article
- Sequential Regulation of Maternal mRNAs through a Conserved cis-Acting Element in Their 3' UTRs.Cell reports · 2018Article
- Review
- Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.PLoS genetics · 2018Article
- Shep regulatesDevelopment (Cambridge, England) · 2018Article
- No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo.PloS one · 2018Article
- Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals.Development (Cambridge, England) · 2016Article
- Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development.Development genes and evolution · 2015Article
- Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.Genome biology · 2015Article
- Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.G3 (Bethesda, Md.) · 2015Article
- The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library.Development (Cambridge, England) · 2014Article
- Synaptic control of local translation: the plot thickens with new characters.Cellular and molecular life sciences : CMLS · 2014Review
- Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis.G3 (Bethesda, Md.) · 2014Article
- Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The translational regulators Nanos (Nos) and Pumilio (Pum) work together to regulate the morphogenesis of dendritic arborization (da) neurons of the Drosophila larval peripheral nervous system. In contrast, Nos and Pum function in opposition to one another in the neuromuscular junction to regulate the morphogenesis and the electrophysiological properties of synaptic boutons. Neither the cellular functions of Nos and Pum nor their regulatory targets in neuronal morphogenesis are known. Here we show that Nos and Pum are required to maintain the dendritic complexity of da neurons during larval growth by promoting the outgrowth of new dendritic branches and the stabilization of existing dendritic branches, in part by regulating the expression of cut and head involution defective. Through an RNA interference screen we uncover a role for the translational co-factor Brain Tumor (Brat) in dendrite morphogenesis of da neurons and demonstrate that Nos, Pum, and Brat interact genetically to regulate dendrite morphogenesis. In the neuromuscular junction, Brat function is most likely specific for Pum in the presynaptic regulation of bouton morphogenesis. Our results reveal how the combinatorial use of co-regulators like Nos, Pum and Brat can diversify their roles in post-transcriptional regulation of gene expression for neuronal morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.