ReviewMicrobiology and molecular biology reviews : MMBR2012
Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.
Review in Microbiology and molecular biology reviews : MMBR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed.
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- Differential Binding of ΔFN3 Proteins ofInternational journal of molecular sciences · 2025Article
- Mycobacterium jinjuensis sp. nov., a Novel Acid-Fast Bacterium Isolated from a Pneumonia Patient.Current microbiology · 2025Article
- Identification of potential inhibitors of dihydrofolate reductase (DHFR) through blocking the folate biosynthetic pathway ofRSC advances · 2025Article
- Biocontrol of Mycotoxigenic Fungi by Actinobacteria.Journal of fungi (Basel, Switzerland) · 2024Review
- A modular toolkit for environmentalApplied and environmental microbiology · 2024Article
- Utilizing novel Escherichia coli-specific conserved signature proteins for enhanced monitoring of recreational water quality.MicrobiologyOpen · 2024Article
- Gut microbiota and chronic rhinosinusitis: a two-sample Mendelian randomization study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Toward Characterizing Environmental Sources of Non-tuberculous Mycobacteria (NTM) at the Species Level: A Tutorial Review of NTM Phylogeny and Phylogenetic Classification.ACS environmental Au · 2024Review
- Who inhabits the built environment? A microbiological point of view on the principal bacteria colonizing our urban areas.Frontiers in microbiology · 2024Review
- Genome characterization and taxonomy of Actinomyces acetigenes sp. nov., and Actinomyces stomatis sp. nov., previously isolated from the human oral cavity.BMC genomics · 2023Article
- Seasonal Changes in the Microbial Communities on Lettuce (Journal of microbiology and biotechnology · 2023Article
- Complete Genome Sequences of Cluster F1 Mycobacteriophages Akhila and MilanaBonita.Microbiology resource announcements · 2023Article
- A peptide encoded by a highly conserved gene belonging to the genusFrontiers in plant science · 2023Article
- Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum.Microbiology spectrum · 2022Article
- HIV complicated withInfectious medicine · 2022Article
- A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum.Scientific data · 2022Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phylum Actinobacteria harbors many important human pathogens and also provides one of the richest sources of natural products, including numerous antibiotics and other compounds of biotechnological interest. Thus, a reliable phylogeny of this large phylum and the means to accurately identify its different constituent groups are of much interest. Detailed phylogenetic and comparative analyses of >150 actinobacterial genomes reported here form the basis for achieving these objectives. In phylogenetic trees based upon 35 conserved proteins, most of the main groups of Actinobacteria as well as a number of their superageneric clades are resolved. We also describe large numbers of molecular markers consisting of conserved signature indels in protein sequences and whole proteins that are specific for either all Actinobacteria or their different clades (viz., orders, families, genera, and subgenera) at various taxonomic levels. These signatures independently support the existence of different phylogenetic clades, and based upon them, it is now possible to delimit the phylum Actinobacteria (excluding Coriobacteriia) and most of its major groups in clear molecular terms. The species distribution patterns of these markers also provide important information regarding the interrelationships among different main orders of Actinobacteria. The identified molecular markers, in addition to enabling the development of a stable and reliable phylogenetic framework for this phylum, also provide novel and powerful means for the identification of different groups of Actinobacteria in diverse environments. Genetic and biochemical studies on these Actinobacteria-specific markers should lead to the discovery of novel biochemical and/or other properties that are unique to different groups of Actinobacteria.
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