ArticleJournal of the International Neuropsychological Society : JINS2012
Processing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum.
Article in Journal of the International Neuropsychological Society : JINS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 78 citations in OpenAlex.
- The role of corpus callosum development in functional connectivity and cognitive processing.PloS one · 2012Trial
- Long-term cognitive outcomes of Chiari II malformation and corpus callosum abnormalities in myelomeningocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Sex-specific white matter alterations in children exposed to high pregestational BMI.Obesity (Silver Spring, Md.) · 2025Article
- Reduced Interhemispheric Coherence and Cognition in Children with Fetal Alcohol Spectrum Disorder (FASD)-A Quantitative EEG Study.Neuropediatrics · 2024Article
- Obesity is associated with alterations in anatomical connectivity of frontal-corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The corpus callosum and creativity revisited.Frontiers in human neuroscience · 2024Article
- Verbal problem-solving in agenesis of the corpus callosum: Analysis using semantic similarity.Neuropsychology · 2023Article
- Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling.Journal of autism and developmental disorders · 2022Article
- Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy.Brain communications · 2022Article
- Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum.Journal of the International Neuropsychological Society : JINS · 2021Article
- Precocious White Matter Inflammation and Behavioural Inflexibility Precede Learning and Memory Impairment in the TgAPP21 Rat Model of Alzheimer Disease.Molecular neurobiology · 2021Article
- Alexithymia and somatization in agenesis of the corpus callosum.Social cognitive and affective neuroscience · 2021Article
- Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer's disease.GeroScience · 2021Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- Processing speed is related to striatal dopamine transporter availability in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Integration Between Cerebral Hemispheres Contributes to Defense Mechanisms.Frontiers in psychology · 2020Article
- The Neuropsychological Syndrome of Agenesis of the Corpus Callosum.Journal of the International Neuropsychological Society : JINS · 2019Review
- White Matter Connectome Edge Density in Children with Autism Spectrum Disorders: Potential Imaging Biomarkers Using Machine-Learning Models.Brain connectivity · 2019Article
- Awareness of consequences in agenesis of the corpus callosum: Semantic analysis of responses.Neuropsychology · 2019Article
- D-KEFS ST Failure Identifies Multiple Sclerosis Patients With Worse Objective and Self-Perceived Physical and Cognitive Disability.Frontiers in psychology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Corpus callosum malformation and dysfunction are increasingly recognized causes of cognitive and behavioral disability. Individuals with agenesis of the corpus callosum (AgCC) offer unique insights regarding the cognitive skills that depend specifically upon callosal connectivity. We examined the impact of AgCC on cognitive inhibition, flexibility, and processing speed using the Color-Word Interference Test (CWIT) and Trail Making Test (TMT) from the Delis-Kaplan Executive Function System. We compared 36 individuals with AgCC and IQs within the normal range to 56 matched controls. The AgCC cohort was impaired on timed measures of inhibition and flexibility; however, group differences on CWIT Inhibition, CWIT Inhibition/Switching and TMT Number-Letter Switching appear to be largely explained by slow performance in basic operations such as color naming and letter sequencing. On CWIT Inhibition/Switching, the AgCC group was found to commit significantly more errors which suggests that slow performance is not secondary to a cautious strategy. Therefore, while individuals with agenesis of the corpus callosum show real deficits on tasks of executive function, this impairment appears to be primarily a consequence of slow cognitive processing. Additional studies are needed to investigate the impact of AgCC on other aspects of higher order cortical function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.