ArticleISRN neurology2011
Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease.
Article in ISRN neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Trial
- Research progress on the association of insulin resistance with type 2 diabetes mellitus and Alzheimer's disease.Metabolic brain disease · 2024Review
- Investigation of Cyclo-Z Therapeutic Effect on Insulin Pathway in Alzheimer's Rat Model: Biochemical and Electrophysiological Parameters.Molecular neurobiology · 2023Article
- Hot Spots for the Use of Intranasal Insulin: Cerebral Ischemia, Brain Injury, Diabetes Mellitus, Endocrine Disorders and Postoperative Delirium.International journal of molecular sciences · 2023Review
- Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress.Antioxidants & redox signaling · 2022Review
- A mini-screen to identify the role of microRNAs in the Drosophila Insulin-Producing cells regulating lifespan.microPublication biology · 2022Article
- The Role of Molecular and Inflammatory Indicators in the Assessment of Cognitive Dysfunction in a Mouse Model of Diabetes.International journal of molecular sciences · 2021Article
- Alzheimer's Disease and Protein Kinases.Advances in experimental medicine and biology · 2021Article
- Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in aFrontiers in neuroscience · 2019Article
- Article
- Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats.PloS one · 2017Article
- Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study.Neuropsychology · 2016Article
- Role of insulin resistance in Alzheimer's disease.Metabolic brain disease · 2015Review
- Brain metabolic dysfunction at the core of Alzheimer's disease.Biochemical pharmacology · 2014Review
- Relationships between diabetes and cognitive impairment.Endocrinology and metabolism clinics of North America · 2014Review
- Mechanisms linking brain insulin resistance to Alzheimer's disease.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin and IGF seem to be important players in modulating brain aging. Neurons share more similarities with islet cells than any other human cell type. Insulin and insulin receptors are diffusely found in the brain, especially so in the hippocampus. Caloric restriction decreases insulin resistance, and it is the only proven mechanism to expand lifespan. Conversely, insulin resistance increases with age, obesity, and sedentarism, all of which have been shown to be risk factors for late-onset Alzheimer's disease (AD). Hyperphagia and obesity potentiate the production of oxidative reactive species (ROS), and chronic hyperglycemia accelerates the formation of advanced glucose end products (AGEs) in (pre)diabetes-both mechanisms favoring a neurodegenerative milieu. Prolonged high cerebral insulin concentrations cause microvascular endothelium proliferation, chronic hypoperfusion, and energy deficit, triggering β-amyloid oligomerization and tau hyperphosphorylation. Insulin-degrading enzyme (IDE) seems to be the main mechanism in clearing β-amyloid from the brain. Hyperinsulinemic states may deviate IDE utilization towards insulin processing, decreasing β-amyloid degradation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.