ArticlePLoS neglected tropical diseases2012
The transcriptome analysis of Strongyloides stercoralis L3i larvae reveals targets for intervention in a neglected disease.
Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Introduction toJournal of nematology · 2024Article
- Novel insights into the somatic proteome of Strongyloides stercoralis infective third-stage larvae.Parasites & vectors · 2023Article
- Promising effects of herbal compounds against strongyloidiasis: a systematic review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Evaluation of the Immunomodulatory Effect of the Recombinant 14-3-3 and Major Antigen Proteins ofVaccines · 2022Article
- Identification of miRNAs of Strongyloides stercoralis L1 and iL3 larvae isolated from human stool.Scientific reports · 2022Article
- Prevalence of Strongyloides stercoralis infection and hyperinfection syndrome among renal allograft recipients in Central Europe.Scientific reports · 2018Article
- Immuno-proteomic analysis of Trichinella spiralis, T. pseudospiralis, and T. papuae extracts recognized by human T. spiralis-infected sera.Parasitology research · 2018Article
- "Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".PLoS neglected tropical diseases · 2017Review
- Perusal of parasitic nematode 'omics in the post-genomic era.Molecular and biochemical parasitology · 2017Review
- Identification of antigenic proteins in Strongyloides stercoralis by proteomic analysis.Parasitology research · 2017Article
- A transcriptomic insight into the infective juvenile stage of the insect parasitic nematode, Heterorhabditis indica.BMC genomics · 2016Article
- Article
- Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction.Nature genetics · 2014Article
- Article
- RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStrongyloidiasis is one of the most neglected diseases distributed worldwide with endemic areas in developed countries, where chronic infections are life threatening. Despite its impact, very little is known about the molecular biology of the parasite involved and its interplay with its hosts. Next generation sequencing technologies now provide unique opportunities to rapidly address these questions. PRINCIPAL
findingsHere we present the first transcriptome of the third larval stage of S. stercoralis using 454 sequencing coupled with semi-automated bioinformatic analyses. 253,266 raw sequence reads were assembled into 11,250 contiguous sequences, most of which were novel. 8037 putative proteins were characterized based on homology, gene ontology and/or biochemical pathways. Comparison of the transcriptome of S. strongyloides with those of other nematodes, including S. ratti, revealed similarities in transcription of molecules inferred to have key roles in parasite-host interactions. Enzymatic proteins, like kinases and proteases, were abundant. 1213 putative excretory/secretory proteins were compiled using a new pipeline which included non-classical secretory proteins. Potential drug targets were also identified.
conclusionsOverall, the present dataset should provide a solid foundation for future fundamental genomic, proteomic and metabolomic explorations of S. stercoralis, as well as a basis for applied outcomes, such as the development of novel methods of intervention against this neglected parasite.
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