ArticlePloS one2012
Impairment of vowel articulation as a possible marker of disease progression in Parkinson's disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 169 citations in OpenAlex.
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Speech treatment in Parkinson's disease: Randomized controlled trial (RCT).Movement disorders : official journal of the Movement Disorder Society · 2018Trial
- What can vowel acoustics reveal about the communicative participation of people living with ALS?Amyotrophic lateral sclerosis & frontotemporal degeneration · 2026Article
- Aerodynamic and Acoustic Characteristics of Nasal Airflow in Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease.Annals of neurology · 2026Article
- Spontaneous speech enables scalable digital phenotyping of physical functional deficits in aging.npj aging · 2026Article
- Vowel Production Associated with Cantonese Speakers of Parkinson's Disease.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2026Article
- Vowel acoustic parameters in speech assessment and rehabilitation of minimally verbal and speech-motor-impaired autistic children: a narrative review.Frontiers in human neuroscience · 2026Review
- Comparing token-based and trajectory-based vowel space metrics for assessing speech in Parkinson's disease.PloS one · 2026Article
- Exploring Bidirectional Associations Between Voice Acoustics and Objective Motor Metrics in Parkinson's Disease.Brain sciences · 2025Article
- Speech Markers of Parkinson's Disease: Phonological Features and Acoustic Measures.Brain sciences · 2025Article
- Speech Differences between Multiple System Atrophy and Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Spectro-Image Analysis with Vision Graph Neural Networks and Contrastive Learning for Parkinson's Disease Detection.Journal of imaging · 2025Article
- Left hemisphere lateralization in unilateral upper motor neuron dysarthria via quantitative acoustic analysis.Scientific reports · 2025Article
- Automatic speech analysis combined with machine learning reliably predicts the motor state in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Vocal Feature Changes for Monitoring Parkinson's Disease Progression-A Systematic Review.Brain sciences · 2025Review
- Variability in Vowel Space in Parkinson's Disease: Associations With Cognitive and Motor Impairment.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Ethnokinesiology: towards a neuromechanical understanding of cultural differences in movement.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the current study was to survey if vowel articulation in speakers with Parkinson's disease (PD) shows specific changes in the course of the disease.
method67 patients with PD (42 male) and 40 healthy speakers (20 male) were tested and retested after an average time interval of 34 months. Participants had to read a given text as source for subsequent calculation of the triangular vowel space area (tVSA) and vowel articulation index (VAI). Measurement of tVSA and VAI were based upon analysis of the first and second formant of the vowels /α/, /i/and /u/ extracted from defined words within the text.
resultsAt first visit, VAI values were reduced in male and female PD patients as compared to the control group, and showed a further decrease at the second visit. Only in female Parkinsonian speakers, VAI was correlated to overall speech impairment based upon perceptual impression. VAI and tVSA were correlated to gait impairment, but no correlations were seen between VAI and global motor impairment or overall disease duration. tVSA showed a similar reduction in the PD as compared to the control group and was also found to further decline between first and second examination in female, but not in male speakers with PD.
conclusionsMeasurement of VAI seems to be superior to tVSA in the description of impaired vowel articulation and its further decline in the course of the disease in PD. Since impairment of vowel articulation was found to be independent from global motor function but correlated to gait dysfunction, measurement of vowel articulation might have a potential to serve as a marker of axial disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.