ArticleInternational journal of clinical rheumatology2011
The potential importance of Toll-like receptors in ankylosing spondylitis.
Article in International journal of clinical rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling.Inflammation · 2023Article
- Integrative analysis of long non-coding RNA and messenger RNA expression in toll-like receptor 4-primed mesenchymal stem cells of ankylosing spondylitis.Annals of translational medicine · 2021Article
- Targeting Toll-like Receptor (TLR) Pathways in Inflammatory Arthritis: Two Better Than One?Biomolecules · 2021Review
- Article
- How to translate basic knowledge into clinical application of biologic therapy in spondyloarthritis.Clinical & developmental immunology · 2013Review
- The role of Vitamin D in immuno-inflammatory responses in Ankylosing Spondylitis patients with and without Acute Anterior Uveitis.Journal of medicine and lifeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cells involved in innate immunity scan for pathogens via extracellular and intracellular (endosomal) pattern recognition receptors (PRRs). Engagement of PRRs by a specific ligand results in downstream activation of intracellular inflammatory cascades. There is emerging evidence indicating that one class of PRR, the Toll-like receptor (TLR) plays a potential role in the pathogenesis of spondyloarthropathies. Since certain Gram-negative bacteria are known to act as triggers for reactive arthritis, there has been much interest in studying the role of TLRs in spondyloarthropathies. In this article, we introduce the immunology of TLRs followed by a discussion of their potential role in ankylosing spondylitis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.