Evidence map›Paper›PMID 22389583›Full record

ArticleMaterials today (Kidlington, England)2011

Magnetite Nanoparticles for Medical MR Imaging.

Zachary R Stephen, Forrest M Kievit, Miqin Zhang

Registry-linked trialAbstract read
In one paragraph

Article in Materials today (Kidlington, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06551805 (Clinical Research Protocol of Ferumoxytol for Magnetic Resonance Enhancement Imaging in Patients With Atherosclerosis.), which is not on this map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06551805 recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Research Protocol of Ferumoxytol for Magnetic Resonance Enhancement Imaging in Patients With Atherosclerosis.

TypeobservationalSponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2024 to 2026Enrolled100ConditionsAtherosclerosisArmsSafety assessment of Ferumoxytol., Assessment of the diagnostic value of Ferumoxytol for MR angiography.
3 · Its place in the literature

Who cites it

134 citing papers in PubMed.

  1. Effect of LaACS omega · 2026
    Article
  2. Review
  3. Article
  4. Hybrid FeInternational journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Tailored Magnetic FeDiagnostics (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Iron Oxide Nanoparticle-Based TNanomaterials (Basel, Switzerland) · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review.International journal of molecular sciences · 2023
    Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary R StephenDepartment of Materials Science and Engineering, University of Washington Seattle, WA 98195 USA.
Forrest M Kievit
Miqin Zhang

Funding

Multifuctional Nanovector For Diagnosis And Treatment Of Pediatric Brain CancerR01EB006043 · NIBIB · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2007 to 2010
$1.6M
Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
Nanovectors For Brain Tumor Diagnosis And TreatmentR01CA134213 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2007 to 2011
$1.5M
NCI NIH HHS R01 CA134213NCI NIH HHS T32 CA138312NIBIB NIH HHS R01 EB006043
6 · The paper itself

Abstract

Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. Iron oxide nanoparticles (SPIONs) in particular have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties of easy modification for improved in vivo kinetics and multifunctionality. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and an outlook on the translational potential of SPIONs.

Identifiers

PMID22389583
PMCPMC3290401

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.