ReviewThe Journal of biological chemistry2012
Structure-function relationships in [FeFe]-hydrogenase active site maturation.
Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 75 citations in OpenAlex.
- The H-cluster of [FeFe] Hydrogenases: Its Enzymatic Synthesis and Parallel Inorganic Semisynthesis.Accounts of chemical research · 2024Article
- Genome-Scale Mining of Acetogens of the GenusMicrobiology spectrum · 2022Article
- Lewis acid protection turns cyanide containing [FeFe]-hydrogenase mimics into proton reduction catalysts.Dalton transactions (Cambridge, England : 2003) · 2022Article
- Extremophilic Oxidoreductases for the Industry: Five Successful Examples With Promising Projections.Frontiers in bioengineering and biotechnology · 2021Review
- Biosynthesis of the catalytic H-cluster of [FeFe] hydrogenase: the roles of the Fe-S maturase proteins HydE, HydF, and HydG.Chemical science · 2020Review
- Structural characterization of HypX responsible for CO biosynthesis in the maturation of NiFe-hydrogenase.Communications biology · 2019Article
- Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF.International journal of molecular sciences · 2018Review
- Photochemical Dynamics of a Trimethyl-Phosphine Derivatized [FeFe]-Hydrogenase Model Compound.Chemical physics · 2018Article
- Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE.Nature chemistry · 2016Article
- CO and CN- syntheses by [FeFe]-hydrogenase maturase HydG are catalytically differentiated events.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cysteine as a ligand platform in the biosynthesis of the FeFe hydrogenase H cluster.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Increasing the rate of hydrogen oxidation without increasing the overpotential: a bio-inspired iron molecular electrocatalyst with an outer coordination sphere proton relay.Chemical science · 2015Article
- [FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis.Biochemistry · 2015Article
- Radical S-adenosyl-L-methionine chemistry in the synthesis of hydrogenase and nitrogenase metal cofactors.The Journal of biological chemistry · 2015Review
- Radical S-adenosylmethionine enzymes.Chemical reviews · 2014Review
- A nonmitochondrial hydrogen production in Naegleria gruberi.Genome biology and evolution · 2014Article
- Expression of Shewanella oneidensis MR-1 [FeFe]-hydrogenase genes in Anabaena sp. strain PCC 7120.Applied and environmental microbiology · 2012Article
- Biochemical analysis of the interactions between the proteins involved in the [FeFe]-hydrogenase maturation process.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the discovery that, despite the active site complexity, only three gene products suffice to obtain active recombinant [FeFe]-hydrogenase, significant light has been shed on this process. Both the source of the CO and CN(-) ligands to iron and the assembly site of the catalytic subcluster are known, and an apo structure of HydF has been published recently. However, the nature of the substrate(s) for the synthesis of the bridging dithiolate ligand to the subcluster remains to be established. From both spectroscopy and model chemistry, it is predicted that an amine function in this ligand plays a central role in catalysis, acting as a base in the heterolytic cleavage of hydrogen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.