ArticleJournal of bacteriology2012
Identification of the HetR recognition sequence upstream of hetZ in Anabaena sp. strain PCC 7120.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Coordination of NProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A proteolytic pathway coordinates cell division and heterocyst differentiation in the cyanobacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Terminal heterocyst differentiation in the Anabaena patA mutant as a result of post-transcriptional modifications and molecular leakage.PLoS computational biology · 2022Article
- Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria.Frontiers in cell and developmental biology · 2022Review
- HetF Protein Is a New Divisome Component in a Filamentous and Developmental Cyanobacterium.mBio · 2021Article
- The small CaBMC microbiology · 2020Article
- Expression from DIF1-motif promoters of hetR and patS is dependent on HetZ and modulated by PatU3 during heterocyst differentiation.PloS one · 2020Article
- cyAbrB Transcriptional Regulators as Safety Devices To Inhibit Heterocyst Differentiation inJournal of bacteriology · 2019Article
- Manipulation of Pattern of Cell Differentiation in aLife (Basel, Switzerland) · 2018Article
- Three Substrains of the Cyanobacterium Anabaena sp. Strain PCC 7120 Display Divergence in Genomic Sequences andJournal of bacteriology · 2018Article
- Functional Overlap ofJournal of bacteriology · 2018Article
- The composition of the global and feature specific cyanobacterial core-genomes.Frontiers in microbiology · 2015Article
- The trpE gene negatively regulates differentiation of heterocysts at the level of induction in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2015Article
- Deep sequencing of HetR-bound DNA reveals novel HetR targets in Anabaena sp. strain PCC7120.BMC microbiology · 2014Article
- Expanding the direct HetR regulon in Anabaena sp. strain PCC 7120.Journal of bacteriology · 2014Article
- ppGpp metabolism is involved in heterocyst development in the cyanobacterium Anabaena sp. strain PCC 7120.Journal of bacteriology · 2013Article
- Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HetR is the master regulator of heterocyst differentiation in Anabaena sp. strain PCC 7120 and has been found to specifically bind to an inverted-repeat-containing region upstream of hetP, a heterocyst differentiation gene. However, no such inverted-repeat sequence can be found in promoters of other genes in the genome. hetZ is a gene involved in early heterocyst differentiation. As shown with the gfp reporter gene, transcription from P(hetZ) was correlated to the expression level of hetR and inhibition by RGSGR, the pentapeptide derived from the C terminus of PatS. As detected by electrophoretic mobility shift assay, a recombinant HetR showed specific binding to the region upstream of hetZ, and the binding was inhibited by RGSGR. Tests of a series of the upstream fragments delimited the HetR-binding site to a 40-bp region that shows similarity to that upstream of hetP. The introduction of substitutions of bases conserved in the two HetR-binding sites showed that at least 12 bases are required for recognition by HetR. Deletion of a 51-bp region containing the HetR-binding site completely eliminated the transcription activity of P(hetZ). Based on the HetR recognition sequence of hetZ, those upstream of hetR and patA are proposed.
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