ArticleNature neuroscience2012
Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.
Article in Nature neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Distinct types of dendritic CaScience advances · 2026Article
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.Science (New York, N.Y.) · 2025Article
- Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3.Nature communications · 2025Article
- Cholinergic regulation of dendritic CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differences in the consolidation by spontaneous and evoked ripples in the presence of active dendrites.PLoS computational biology · 2024Article
- Distinguishing examples while building concepts in hippocampal and artificial networks.Nature communications · 2024Article
- Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Ion-channel degeneracy and heterogeneities in the emergence of complex spike bursts in CA3 pyramidal neurons.The Journal of physiology · 2023Article
- The Polyamine Spermine Potentiates the Propagation of Negatively Charged Molecules through the Astrocytic Syncytium.Biomolecules · 2022Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials.Neuroscience bulletin · 2022Article
- Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model.Neuroscience · 2022Article
- Assessing Local and Branch-specific Activity in Dendrites.Neuroscience · 2022Article
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- Distinct dendritic CaeLife · 2021Article
- Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses.Nature communications · 2021Article
- Topographic heterogeneity of intrinsic excitability in mouse hippocampal CA3 pyramidal neurons.Journal of neurophysiology · 2020Article
- Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity.PLoS biology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. It is generally thought that proximal synapses from the mossy fibers activate these neurons most efficiently, whereas distal inputs from the perforant path have a weaker modulatory influence. We used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two distinct dendritic domains. In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na(+) channel-mediated dendritic spikes are efficiently initiated by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed a high Na(+)-to-K(+) conductance density ratio, providing ideal conditions for active backpropagation and dendritic spike initiation. Dendritic spikes may enhance the computational power of CA3 pyramidal neurons in the hippocampal network.
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