Evidence map›Paper›PMID 22388629›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2012

Radiolabelled RGD peptides for imaging and therapy.

F C Gaertner, H Kessler, H-J Wester, M Schwaiger, A J Beer

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Article
  2. EGFR- and Integrin αInternational journal of molecular sciences · 2024
    Review
  3. Review
  4. Review
  5. Article
  6. Peptides for trans-blood-brain barrier delivery.Journal of labelled compounds & radiopharmaceuticals · 2023
    Review
  7. Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation.Journal of the American Chemical Society · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. A Dimeric FAP-Targeting Small-Molecule Radioconjugate with High and Prolonged Tumor Uptake.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. [International journal of molecular sciences · 2021
    Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

F C GaertnerDepartment of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 Munich, Germany. florian.gaertner@tum.de
H Kessler
H-J Wester
M Schwaiger
A J Beer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging of angiogenesis has become increasingly important with the rising use of targeted antiangiogenic therapies like bevacizumab (Avastin). Non-invasive assessment of angiogenic activity is in this respect interesting, e.g. for response assessment of such targeted antiangiogenic therapies. One promising approach of angiogenesis imaging is imaging of specific molecular markers of the angiogenic cascade like the integrin α(v)β(3). For molecular imaging of integrin expression, the use of radiolabelled peptides is still the only approach that has been successfully translated into the clinic. In this review we will summarize the current data on imaging of α(v)β(3) expression using radiolabelled RGD peptides with a focus on tracers already in clinical use. A perspective will be presented on the future clinical use of radiolabelled RGD peptides including an outlook on potential applications for radionuclide therapy.

Indexed as

Angiogenesis InhibitorsCopper RadioisotopesGalactoseGallium RadioisotopesHumansIntegrinsNeoplasmsNeovascularization, PathologicOligopeptidesPeptidesPeptides, CyclicPolyethylene GlycolsRadiopharmaceuticalsTechnetiumTomography, Emission-Computed, Single-Photon18F-RGD-K5AH 111585Angiogenesis Inhibitorsarginyl-glycyl-aspartic acidCopper Radioisotopesfluorogalacto-RGDGalactoseGallium RadioisotopesIntegrinsOligopeptidesPeptidesPeptides, CyclicPolyethylene GlycolsRadiopharmaceuticalsTechnetium

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.